Phospho-Torc2/Crtc2 (Ser171) Antibody #2892
Inquiry Info. # 2892
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Product Specifications
| REACTIVITY | |
| SENSITIVITY | Transfected Only |
| MW (kDa) | 85 |
| SOURCE | Rabbit |
Product Information
Storage
Specificity / Sensitivity
Source / Purification
Background
CRTC2/TORC2-related proteins CRTC1/TORC1 and CRTC3/TORC3 also act as CREB co-activators (2,3). CRTC1/TORC1, CRTC2/TORC2 and CRTC3/TORC3 associate with the HTLV Tax protein to promote Tax-dependent transcription of HTLV-1 long terminal repeats (6,7). CRTC1/TORC1 is highly phosphorylated at Ser151 in mouse hypothalamic cells under basal conditions (8). When these cells are exposed to cAMP or a calcium activator, CRTC1/TORC1 is dephosphorylated and translocates into the nucleus (8). CRTC1/TORC1 is essential for energy balance and fertility (8).
- Hinke, S.A. et al. (2004) J Physiol 558, 369-80.
- Conkright, M.D. et al. (2003) Mol Cell 12, 413-23.
- Iourgenko, V. et al. (2003) Proc Natl Acad Sci U S A 100, 12147-52.
- Screaton, R.A. et al. (2004) Cell 119, 61-74.
- Koo, S.H. et al. (2005) Nature 437, 1109-11.
- Koga, H. et al. (2004) J Biol Chem 279, 52978-83.
- Siu, Y.T. et al. (2006) J Virol 80, 7052-9.
- Altarejos, J.Y. et al. (2008) Nat Med 14, 1112-7.
Alternate Names
CREB regulated transcription coactivator 2; CREB-regulated transcription coactivator 2; CRTC2; RP11-422P24.6; TORC-2; TORC2; Transducer of CREB protein 2; transducer of regulated cAMP response element-binding protein (CREB) 2; Transducer of regulated cAMP response element-binding protein 2
Limited Uses
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