Render Target: STATIC
Render Timestamp: 2024-10-09T09:57:55.104Z
Commit: f04ddd7fea9fb3592f59f61482fcb94610d25cbe
1% for the planet logo
PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

POM121 Antibody #83525

Filter:
  • WB

    Supporting Data

    REACTIVITY H M R Mk
    SENSITIVITY Endogenous
    MW (kDa) 150
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    POM121 Antibody recognizes endogenous levels of total POM121 protein. This antibody detects all POM121 protein variants, including POM121A, POM121B, and POM121C.

    Species Reactivity:

    Human, Mouse, Rat, Monkey

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human POM121 protein. Antibodies are purified by peptide affinity chromatography.

    Background

    The nuclear pore complex (NPC) is a multi-subunit protein channel that spans the nuclear envelope and is responsible for the nucleocytoplasmic trafficking of RNA, proteins, and ribonucleoproteins (1,2). POM121, also referred to as nucleoporin Nup121, is a transmembrane nuclear protein that is an essential component of the NPC. POM121 expression is increased in aggressive, lethal prostate cancer and contributes to cancer progression and aggressiveness by enhancing the nuclear import of oncogenic transcription factors, such as E2F1, MYC, and GATA2, allowing for the upregulation of target genes (3). Elevated levels of POM121 have also been associated with poor outcome in patients with colorectal, lung, and laryngeal cancers, and it may serve as a prognostic biomarker for these cancer types (4-6).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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