PROS1 (E7F5H) Rabbit mAb #75390
- WB
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 78, 80 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
PROS1 is well known for its anticoagulant role during thrombosis (2,3). The anticoagulation function of PROS1 is exerted by both intrinsic and extrinsic mechanisms. Extrinsically, PROS1 functions as a cofactor in the TFPI (tissue factor pathway inhibitor) to inhibit Factor Xa generation and prevent coagulation (4). Intrinsically, PROS1 functions as a cofactor for activated protein C (aPC) (4). PROS1-aPC promotes degradation of Factors V and VIII, and prevents coagulation and thrombin formation (5). Another important function of PROS1 is as a ligand activator of the TAM (Tyro3, Axl, and MerTK) RTK family receptor. Among the TAM family members, PROS1 binds and activates Tyro3 and MerTK (6-8). The ligand/receptor interactions activate multiple downstream signaling pathways, such as STAT, ERK, Akt, NF-kB, Bcl-2, and FAK (9). PROS1/TAM interactions play important roles in immune and nervous inflammation and homeostasis, cancer development, and immune-related multiple sclerosis (9-11).
- Hafizi, S. and Dahlbäck, B. (2006) FEBS J 273, 5231-44.
- Rothlin, C.V. et al. (2015) Annu Rev Immunol 33, 355-91.
- Suleiman, L. et al. (2013) Crit Rev Oncol Hematol 88, 637-54.
- Gierula, M. and Ahnström, J. (2020) J Thromb Haemost 18, 2801-2811.
- Fernández, J.A. et al. (2009) Haematologica 94, 1721-31.
- Stitt, T.N. et al. (1995) Cell 80, 661-70.
- Tsou, W.I. et al. (2014) J Biol Chem 289, 25750-63.
- Lew, E.D. et al. (2014) Elife 3, e03385. doi: 10.7554/eLife.03385.
- Aehnlich, P. et al. (2021) Cancers (Basel) 13, 1195. doi: 10.3390/cancers13061195.
- Burstyn-Cohen, T. and Hochberg, A. (2021) Brain Plast 7, 33-46.
- Peeters, M.J.W. et al. (2020) Cancer Immunol Immunother 69, 237-244.
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