Protor-2 (D19A5) Rabbit mAb #12288

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Supporting Data

REACTIVITY	H Mk
SENSITIVITY	Endogenous
MW (kDa)	42
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting

Species Cross-Reactivity Key:

H-Human
Mk-Monkey

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

Protor-2 (D19A5) Rabbit mAb recognizes endogenous levels of total protor-2 protein.

Species Reactivity:

Human, Monkey

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human protor-2 protein.

Background

Protein observed with rictor-1 (protor-1) and protor-2 both interact with rictor and were identified as components of mTORC2 (1). The absence of protor-1 or protor-2 does not affect the assembly of other mTORC2 components into an active complex (2). Protor-1 was shown to be essential for the activation of SGK1 mediated by mTORC2 (2). Protor-2 plays a role in tristetraprolin-mediated mRNA turnover (3).

Database Links

UniProt ID: Q6MZQ0

Entrez-Gene Id: 79899

Limited Uses

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For Research Use Only. Not For Use In Diagnostic Procedures.

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