Render Target: STATIC
Render Timestamp: 2024-10-04T10:05:45.729Z
Commit: f04ddd7fea9fb3592f59f61482fcb94610d25cbe
1% for the planet logo
PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

PRP4K (D27A1) Rabbit mAb #8577

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H R Mk
    SENSITIVITY Endogenous
    MW (kDa) 150
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • R-Rat 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    PRP4K (D27A1) Rabbit mAb recognizes endogenous levels of total PRP4K protein.

    Species Reactivity:

    Human, Rat, Monkey

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys659 of human PRP4K protein.

    Background

    PRP4K (PRP4 kinase) belongs to the Clk (Cdc-like kinase) family that recognizes serine/arginine-rich substrates (1). PRP4K is involved in pre-mRNA splicing and transcriptional regulation by interacting with components of both the U5 snRNP and the NCoR Deacetylase complexes (2,3). PRP6 and PRP31 have been shown to be direct substrates of PRP4K; their phosphorylation by PRP4K contributes to the assembly of a stable spliceosomal B complex (4).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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