REV1 (F6R6I) Rabbit Monoclonal Antibody #56616
- WB
Product Specifications
| REACTIVITY | H Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 150 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
REV1 is critical for the recruitment and assembly of TLS polymerases at DNA damage sites. The C-terminal domain (CTD) of REV1 is essential for its function, making it a potential therapeutic target (4). Expression of the REV1 CTD has a dominant negative effect on TLS, sensitizing cancer cells to DNA-damaging agents (5). Additional REV1 inhibitors have been shown to sensitize cancer cells to radiation and chemotherapy (6-8).
- Sasatani, M. et al. (2020) Genes Environ 42, 9.
- Arianna, G.A. and Korzhnev, D.M. (2024) Genes (Basel) 15, 832. doi: 10.3390/genes15070832.
- Zhu, N. et al. (2022) Front Genet 13, 997970.
- Zaino, A.M. et al. (2024) Bioorg Med Chem 106, 117755.
- Bian, K. et al. (2025) Proc Natl Acad Sci USA 122, e2511136122.
- Wojtaszek, J.L. et al. (2019) Cell 178, 152-159.e11.
- Chen, Y. et al. (2024) J Biomed Sci 31, 55.
- Cheng, J. et al. (2025) Oncol Rep 54, 159. doi: 10.3892/or.2025.8992.
Alternate Names
AIBP80; Alpha integrin-binding protein 80; DNA repair protein REV1; FLJ21523; MGC163283; MGC26225; REV1; REV1 DNA directed polymerase; REV1 homolog; REV1 homolog (S. cerevisiae); REV1- like; Rev1-like terminal deoxycytidyl transferase; REV1, polymerase (DNA directed); REV1L
Limited Uses
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