RGS5 (F6D1S) Rabbit Monoclonal Antibody #93936
- WB
Product Specifications
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 21 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Regulator of G-protein Signaling 5 (RGS5) is primarily expressed in pericytes and vascular smooth muscle cells (VSMCs) (5). RGS5 is a negative regulator of G-proteins, and is involved in maintaining blood pressure homeostatis as well as modulating vascular pathology in cancer (6-8).
- Hollinger, S. and Hepler, J.R. (2002) Pharmacol Rev 54, 527-59.
- Traynor, J.R. and Neubig, R.R. (2005) Mol Interv 5, 30-41.
- Neubig, R.R. and Siderovski, D.P. (2002) Nat Rev Drug Discov 1, 187-97.
- Terzi, D. et al. (2009) Prog Mol Biol Transl Sci 86, 299-333.
- Bondjers, C. et al. (2003) Am J Pathol 162, 721-9.
- Hamzah, J. et al. (2008) Nature 453, 410-4.
- Silini, A. et al. (2012) Cell Mol Life Sci 69, 1167-78.
- Holobotovskyy, V. et al. (2013) Circ Res 112, 781-91.
Alternate Names
MST092; MST106; MST129; MSTP032; MSTP092; MSTP106; MSTP129; regulator of G protein signaling 5; Regulator of G protein signaling-5; Regulator of G-protein signaling 5; regulator of G-protein signalling 5; RGS5
Limited Uses
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