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  3. SAMD9 (F9J1K) Rabbit Monoclonal Antibody
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Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

SAMD9 (F9J1K) Rabbit Monoclonal Antibody #49256

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  • IP

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 190
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    SAMD9 (F9J1K) Rabbit Monoclonal Antibody recognizes endogenous levels of total SAMD9 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala95 of human SAMD9 protein.

    Background

    Innate immunity provides the first line of defense against infectious microbial pathogens through a family of proteins known as pattern-recognition receptors (PRRs), which detect pathogen-associated molecular patterns (PAMPs) consisting of nucleic acids, peptides, peptidoglycans, and lipopolysaccharides (1-4). Sterile alpha motif domain-containing 9 (SAMD9) plays a role in innate immunity by recognizing both cytosolic double-stranded DNA and RNA and functions broadly as an antiviral protein (2-4). SAMD9 has been most studied in the innate immune response to infection by poxviruses (3,4). SAMD9 is evolutionarily conserved, and mutations in human SAMD9 cause a severe multi-system disorder called the MIRAGE syndrome (5-7). SAMD9 contains an N-terminal SAM domain, a nucleic acid binding domain, and a putative STAND (signal transduction adenosine triphosphatases with numerous associated domains) domain (1,8). STAND proteins share a set of conserved domains: a C-terminal PAMPs sensor, a structural NOD domain, and an N-terminal effector that has been shown to bind double-stranded nucleic acids (8). In addition to its antiviral activity, SAMD9 has also been studied in cancer and autoimmune disease. SAMD9 has been shown to act as a tumor suppressor in lung, colon, and breast cancers (9), and has increased expression in rheumatoid arthritis (10). The roles of SAMD9 in innate immunity, autoimmunity, and cancer have resulted in increased research interest as a therapeutic target.

    Alternate Names

    C7orf5; DRIF1; expressed in aggressive fibromatosis; FLJ20073; KIAA2004; MIRAGE; NFTC; OEF1; OEF2; SAM domain-containing protein 9; SAMD9; sterile alpha motif domain containing 9; Sterile alpha motif domain-containing protein 9

    Database Links

    UniProt ID: Q5K651


    Entrez-Gene Id: 54809


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    For Research Use Only. Not for Use in Diagnostic Procedures.
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