Render Target: STATIC
Render Timestamp: 2024-12-06T11:55:35.044Z
Commit: 224419269841c11382c4555dbee545259bf6c379
XML generation date: 2024-09-30 01:57:52.025
Product last modified at: 2024-09-30T08:00:38.564Z
Cell Signaling Technology Logo
1% for the planet logo
PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

SCAMP4 (E8Y6Z) Rabbit mAb #99948

Filter:
  • WB

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 25
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    SCAMP4 (E8Y6Z) Rabbit mAb recognizes endogenous levels of total SCAMP4 protein. Based on observed molecular weight and the sequence of the peptide antigen, this antibody is not expected to cross-react with other SCAMP family members. By western blot, this antibody recognizes a background band of unknown origin at approximately 120 kDa.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro30 of human SCAMP4 protein.

    Background

    Secretory carrier membrane proteins (SCAMPs) are a family of conserved integral membrane proteins localized to membranes of the cell-surface recycling system, including secretory organelles and endosomes. SCAMP1, SCAMP2, SCAMP3, and SCAMP4 are ubiquitously expressed, whereas SCAMP5 exhibits primarily neural expression (1,2).
    SCAMP4 protein is enriched on the surface of senescent cells, and its expression regulates the secretion of SASP (senescence-associated secretory phenotype) factors, including interleukin 6 (IL6), IL7, IL8, growth differentiation factor-15 (GDF-15), and C-X-C motif chemokine ligand 1 (CXCL1) (3).
    For Research Use Only. Not For Use In Diagnostic Procedures.
    Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
    XP is a registered trademark of Cell Signaling Technology, Inc.
    All other trademarks are the property of their respective owners. Visit our Trademark Information page.