|56062T||1 Kit (8 x 20 microliters)||
|p16 INK4A (D3W8G) Rabbit mAb 92803||20 µl||
|p21 Waf1/Cip1 (12D1) Rabbit mAb 2947||20 µl||
||H Mk||21||Rabbit IgG|
|Phospho-Histone H2A.X (Ser139) (20E3) Rabbit mAb 9718||20 µl||
||H M R Mk||15||Rabbit IgG|
|Lamin B1 (D9V6H) Rabbit mAb 13435||20 µl||
||H M R||68, 45||Rabbit IgG|
|HMGB1 (D3E5) Rabbit mAb 6893||20 µl||
||H M R Mk||29||Rabbit IgG|
|IL-6 (D3K2N) Rabbit mAb 12153||20 µl||
|TNF-α (D5G9) Rabbit mAb 6945||20 µl||
||H||18, 25||Rabbit IgG|
|MMP-3 (D7F5B) Rabbit mAb 14351||20 µl||
||H R||60||Rabbit IgG|
|Anti-rabbit IgG, HRP-linked Antibody 7074||100 µl||
Monoclonal antibodies are produced by immunizing rabbits with synthetic peptides corresponding to residues surrounding Ala34 of human p16 INK4A protein, residues near the carboxy-terminus of human p21, residues surrounding Ser139 of human histone H2A.X protein, residues surrounding Lys415 of human lamin B1 protein, residues surrounding Ala137 of human HMGB1 protein, recombinant human IL-6 protein, recombinant human TNF-α protein, and residues surrounding Ser417 of human MMP3 protein.
Senescence is characterized by stable stress-induced proliferative arrest and resistance to mitogenic stimuli, as well as the secretion of proteins such as cytokines, growth factors and proteases. These secreted proteins comprise the senescence-associated secretory phenotype (SASP). Senescent cells are thought to accumulate as an organism ages, and contribute to age-related diseases, including cancer, through promotion of inflammation and disruption of normal cellular function (1,2).
Because there is no single biomarker that can be used to definitively identify senescent cells, researchers must rely on a collection of biomarkers commonly associated with senescence. The Senescence Marker Antibody Sampler Kit provides a collection of antibodies to commonly used biomarkers of senescence-associated cell cycle arrest (p16 INK4A, p21 Waf1/Cip1), senescence-associated DNA damage (gamma-Histone H2A.X), and the SASP (HMGB1, IL-6, TNF-alpha, MMP3). The kit also includes an antibody to Lamin B1, which is frequently reduced in senescent cells.
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