Render Target: STATIC
Render Timestamp: 2024-11-12T09:56:37.606Z
Commit: 3c1f305a63297e594ac8d7bb5424007d592d68be
XML generation date: 2024-08-01 15:28:11.772
Product last modified at: 2024-05-30T07:13:09.780Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

SF3B4 Antibody #80026

Filter:
  • WB

    Supporting Data

    REACTIVITY H M R Mk
    SENSITIVITY Endogenous
    MW (kDa) 48
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    SF3B4 Antibody recognizes endogenous levels of total SF3B4 protein.

    Species Reactivity:

    Human, Mouse, Rat, Monkey

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly420 of human SF3B4 protein. Antibodies are purified by peptide affinity chromatography.

    Background

    SF3B4 is part of the SF3b complex, which associates with the U2 snRNP component of the spliceosome and is essential for spliceosome assembly (1-3). SF3B4 can associate with BMPR-1A to inhibit BMP-mediated cell differentiation (4). Haploinsufficiency of SF3B4 has been described in Nager syndrome, a disease of craniofacial malformation condition (5,6). Increased copy number of SF3B4 has been shown to play a role in hepatocellular carcinoma progression (7-9).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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