SIK3 Antibody #39477
- WB
- IP
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 145 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:100 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
SIK3 was identified in a screen for tumor-associated antigens that promoted cell proliferation and showed increased expression in ovarian cancer (5). Analysis of SIK3 knockout mice identified a key role in skeletal development via regulation of subcellular localization of HDAC4 (6). Additional studies have also found that SIK3 can regulate glucose and lipid metabolism in the liver (7). SIK1 and SIK3 were found to mediate the tumor suppressive activity of LKB1 in models of non-small cell lung cancer (8).
- Wang, Z. et al. (1999) FEBS Lett 453, 135-9.
- Horike, N. et al. (2003) J Biol Chem 278, 18440-7.
- Katoh, Y. et al. (2004) Mol Cell Endocrinol 217, 109-12.
- Dentin, R. et al. (2007) Nature 449, 366-9.
- Charoenfuprasert, S. et al. (2011) Oncogene 30, 3570-84.
- Sasagawa, S. et al. (2012) Development 139, 1153-63.
- Uebi, T. et al. (2012) PLoS One 7, e37803.
- Hollstein, P.E. et al. (2019) Cancer Discov 9, 1606-27.
Limited Uses
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