Render Target: STATIC
Render Timestamp: 2024-11-01T10:00:14.582Z
Commit: 23cb9f61fe67e1e9093fd644a533c4ff516a6463
XML generation date: 2024-08-01 15:29:44.851
Product last modified at: 2024-05-30T07:04:00.921Z
1% for the planet logo
PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

SLMAP Antibody #34161

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H M R Mk
    SENSITIVITY Endogenous
    MW (kDa) 90-95
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    SLMAP Antibody recognizes endogenous levels of total SLMAP protein. Based on antigen sequence, the antibody is predicted to detect isoforms 1-4 and isoform 6 of SLMAP.

    Species Reactivity:

    Human, Mouse, Rat, Monkey

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp464 of human SLMAP protein. Antibodies are purified by peptide affinity chromatography.

    Background

    Sarcolemmal membrane-associated protein (SLMAP) is a tail-anchored membrane protein involved in the docking and membrane fusion process (1). It is also a component of a conserved striatin-interacting phosphatase and kinase complex (STRIPAK) which participates in a variety of cellular processes, including signaling, cell cycle control, cell migration, Golgi assembly, and apoptosis (2-4). There are several isoforms of SLMAP as a result of alternative splicing; shorter isoforms exhibit high expression in cardiac muscle, whereas the longer isoforms are expressed more ubiquitously, but at lower levels (5). As a cardiac membrane protein, SLMAP plays an important role in excitation-contraction coupling and the adrenergic response, and has been identified as a novel regulator of cardiac function (6-8). In support of that function, mutations in the SLMAP gene are associated with Brugada syndrome, a cardiac channelopathy (9). Deregulation of SLMAP expression has also been implicated in type 2 diabetes, and changes in SLMAP expression are linked to hyperglycemia and diabetes (10). Additionally, a novel SLMAP-ALK fusion has been identified in a patient with non-small cell lung cancer (11).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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