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Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

SLMAP (E5F4Y) Rabbit mAb #56310

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H M R Mk
    SENSITIVITY Endogenous
    MW (kDa) 90-95
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    SLMAP (E5F4Y) Rabbit mAb recognizes endogenous levels of total SLMAP protein. Based on antigen sequence, the antibody is predicted to detect isoforms 1-4 and isoform 6 of SLMAP. A band of unknown origin is detected at ~60 kDa.

    Species Reactivity:

    Human, Mouse, Rat, Monkey

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Thr462 of human SLMAP protein.

    Background

    Sarcolemmal membrane-associated protein (SLMAP) is a tail-anchored membrane protein involved in the docking and membrane fusion process (1). It is also a component of a conserved striatin-interacting phosphatase and kinase complex (STRIPAK) which participates in a variety of cellular processes, including signaling, cell cycle control, cell migration, Golgi assembly, and apoptosis (2-4). There are several isoforms of SLMAP as a result of alternative splicing; shorter isoforms exhibit high expression in cardiac muscle, whereas the longer isoforms are expressed more ubiquitously, but at lower levels (5). As a cardiac membrane protein, SLMAP plays an important role in excitation-contraction coupling and the adrenergic response, and has been identified as a novel regulator of cardiac function (6-8). In support of that function, mutations in the SLMAP gene are associated with Brugada syndrome, a cardiac channelopathy (9). Deregulation of SLMAP expression has also been implicated in type 2 diabetes, and changes in SLMAP expression are linked to hyperglycemia and diabetes (10). Additionally, a novel SLMAP-ALK fusion has been identified in a patient with non-small cell lung cancer (11).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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