|93130T||1 Kit (6 x 20 microliters)||
|Stat1 (D1K9Y) Rabbit mAb 14994||20 µl||
||H M R Mk||84, 91||Rabbit IgG|
|Stat2 (D9J7L) Rabbit mAb 72604||20 µl||
||H M||97, 113||Rabbit IgG|
|Stat3 (D1B2J) Rabbit mAb 30835||20 µl||
||H M R||79, 86||Rabbit IgG|
|Stat4 (C46B10) Rabbit mAb 2653||20 µl||
||H M R||81||Rabbit|
|Stat5 (D2O6Y) Rabbit mAb 94205||20 µl||
||H M R||90||Rabbit IgG|
|Stat6 (D3H4) Rabbit mAb 5397||20 µl||
||H M R||110||Rabbit IgG|
|Anti-rabbit IgG, HRP-linked Antibody 7074||100 µl||
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro688 of human Stat1 protein, Leu706 of human Stat2, Pro695 of human Stat3, Lys151 of human Stat4, Leu60 of human Stat5, and Gly582 of human Stat6.
Jaks (Janus Kinases) and Stats (Signal Transducers and Activators of Transcription) are utilized by receptors for a wide variety of ligands including cytokines, hormones, growth factors and neurotransmitters. Jaks, activated via autophosphorylation following ligand-induced receptor aggregation, phosphorylate tyrosine residues on associated receptors, Stat molecules and other downstream signaling proteins (1,2). The phosphorylation of Stat proteins at conserved tyrosine residues activates SH2-mediated dimerization followed rapidly by nuclear translocation. Stat dimers bind to IRE (interferon response element) and GAS (gamma interferon-activated sequence) DNA elements, resulting in the transcriptional regulation of downstream genes (1,2). The remarkable range and specificity of responses regulated by the Stats is determined in part by the tissue-specific expression of different cytokine receptors, Jaks and Stats (2,3), and by the combinatorial coupling of various Stat members to different receptors. Serine phosphorylation in the carboxy-terminal transcriptional activation domain has been shown to regulate the function of Stat1, -2, -3, -4 and -5 (1). Phosphorylation of Stat3 at Ser727 via MAPK or mTOR pathways is required for optimal transcriptional activation in response to growth factors and cytokines including IFN-gamma and CNTF (4,5). Jak/Stat pathways also play important roles in oncogenesis, tumor progression, angiogenesis, cell motility, immune responses and stem cell differentiation (6-11).
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