STEEP Antibody #35136
- WB
- IP
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 28 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Protocol
Specificity / Sensitivity
STEEP Antibody recognizes endogenous levels of total STEEP protein.
Species Reactivity:
Human, Mouse, Rat
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human STEEP protein. Antibodies are purified by peptide affinity chromatography.
Background
STING ER exit protein (STEEP) is a highly conserved, ubiquitously expressed protein, which has been shown to be a positive regulator of the cGAS-STING signaling pathway. Mechanistically, research studies have demonstrated that STEEP constitutively interacts with STING to coordinate STING ER-to-Golgi trafficking, which is an essential step to ensure productive STING-dependent signaling and gene expression in response to viral infection (1).
Limited Uses
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