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SV2A (D1L8S) Rabbit Monoclonal Antibody

SV2A (D1L8S) Rabbit Monoclonal Antibody #66724

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Product Specifications

REACTIVITY	H M R
SENSITIVITY	Endogenous
MW (kDa)	80-100
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting
IP-Immunoprecipitation
IF-Immunofluorescence

Species Cross-Reactivity Key:

H-Human
M-Mouse
R-Rat

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000
Immunoprecipitation	1:50
Immunofluorescence (Frozen)	1:400

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

For a carrier free (BSA and azide free) version of this product see product #28944.

Protocol

Specificity / Sensitivity

SV2A (D1L8S) Rabbit Monoclonal Antibody recognizes endogenous levels of total SV2A protein.

Species Reactivity:

Human, Mouse, Rat

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Phe516 of human SV2A protein.

Background

SV2s are a family of synaptic vesicle proteins expressed in both neurons and endocrine cells. SV2s function in the regulation of synaptic vesicle traffic, cytoplasmic Ca²⁺ levels in the nerve terminal during repetitive stimulation and the facilitation of synaptic transmission. There are three isoforms of SV2: SV2A, SV2B and SV2C. Each of these isoforms are structured similarly but expressed varyingly. SV2C, a minor isoform of SV2, expressed in a small subset of neurons located within the basal forebrain, midbrain and brainstem. SV2B, a major isoform of SV2 is expressed more abundantly, although rarely without the coexpression of SV2A. SV2A, the other major isoform of SV2 is the most widely expressed. SV2A is located in the presynaptic nerve terminals of almost every neuron throughout the nervous system. In addition, it is also located in most neuroendocrine secretory granules (1). SV2A has been identified as a critical protein for proper function of the central nervous system and has been linked to the physiopathology of epilepsy (2). In addition to the epileptic affects of this protein, mutations in it have also been seen to result in schizophrenia (3).

Alternate Names

KIAA0736; SV2; SV2A; synaptic vesicle glycoprotein 2; Synaptic vesicle glycoprotein 2A

Database Links

UniProt ID: Q7L0J3

Entrez-Gene Id: 9900

Limited Uses

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For Research Use Only. Not for Use in Diagnostic Procedures.

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