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3744
TAB2 Antibody

TAB2 Antibody #3744

This product is discontinued

We recommend the following alternatives

  • WB
  • IP
H M R
Storage:

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

TAB2 Antibody detects endogenous levels of TAB2 protein.

Species predicted to react based on 100% sequence homology:

Monkey, Chicken, Bovine

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys556 of TAB2. Antibodies were purified by protein A and peptide affinity chromatography.

TAK1 is a mitogen-activated protein kinase kinase kinase activated by TGF-β and various pro-inflammatory signals (1,2). In vivo, TAK1 activation requires its association with TAK1 binding protein 1 (TAB1), which triggers TAK1 autophosphorylation at Thr184 and Thr187 (3,4). The TAB2 adaptor protein links TAK1 with TRAF6 to mediate TAK1 activation following IL-1 stimulation (5). Once activated, TAK1 phosphorylates the MAPK kinases MKK4 and MKK3/6, which activate JNK and p38 MAPK, respectively. TAK1 and TRAF6 also activate the NF-κB pathway by phosphorylating the NF-κB inducing kinase (NIK) to trigger subsequent activation of IKK (2,6). In addition to TAK1, TAB1 interacts with and activates p38α MAPK (7). Targeted disruption of the TAB1 gene in mice causes a drastic reduction in TAK1 activity and leads to embryonic lethality (8).

  1. Yamaguchi, K. et al. (1995) Science 270, 2008-11.
  2. Ninomiya-Tsuji, J. et al. (1999) Nature 398, 252-6.
  3. Shibuya, H. et al. (1996) Science 272, 1179-82.
  4. Sakurai, H. et al. (2000) FEBS Lett 474, 141-5.
  5. Takaesu, G. et al. (2000) Mol Cell 5, 649-58.
  6. Wang, C. et al. (2001) Nature 412, 346-51.
  7. Ge, B. et al. (2002) Science 295, 1291-4.
  8. Komatsu, Y. et al. (2002) Mech Dev 119, 239-49.
Entrez-Gene Id
23118
Swiss-Prot Acc.
Q9NYJ8
For Research Use Only. Not For Use In Diagnostic Procedures.

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