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TMEM192 (F1E6H) Rabbit Monoclonal Antibody

TMEM192 (F1E6H) Rabbit Monoclonal Antibody #26976

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Product Specifications

REACTIVITY	H M
SENSITIVITY	Endogenous
MW (kDa)
Source/Isotype	Rabbit IgG

Application Key:

IHC-Immunohistochemistry

Species Cross-Reactivity Key:

H-Human
M-Mouse

Product Information

Product Usage Information

This product was developed by CST^® scientists in collaboration with The Michael J. Fox Foundation (MJFF). Our partnership aims to accelerate Parkinson’s disease (PD) research by identifying and developing high-quality monoclonal antibodies for promising PD targets.

Visit the CST Parkinson’s Disease Resource Center to learn more: https://cst-science.com/PD-Resources.

Application	Dilution
Immunohistochemistry (Paraffin)	1:400 - 1:1600

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

TMEM192 (F1E6H) Rabbit Monoclonal Antibody recognizes endogenous levels of total TMEM192 protein.

Species Reactivity:

Human, Mouse

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human TMEM192 protein.

Background

Transmembrane protein 192 (TMEM192) is a lysosomal/late endosomal protein initially discovered in lysosomal membranes isolated from human placenta (1). TMEM192 contains four transmembrane segments with cytosolic N- and C-termini forming homodimers. Notably, unlike most lysosomal membrane proteins, it is devoid of N-glycans (2). TMEM192 tissue expression has been investigated in mice and demonstrated to be ubiquitous. In the mouse brain, TMEM192 expression is found predominantly in the hippocampus, alongside notable presence in the cortex and cerebellum (3). TMEM192 has been identified as an integral component of a signaling axis involved in lysophagy, thereby playing a vital role in maintaining lysosomal integrity (4).

Alternate Names

FLJ38482; OTTHUMP00000219950; TM192; TMEM192; Transmembrane protein 192

Database Links

UniProt ID: Q8IY95

Entrez-Gene Id: 201931

Limited Uses

Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.

Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

For Research Use Only. Not for Use in Diagnostic Procedures.

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