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UCP3 (D6J8K) Rabbit Monoclonal Antibody #97000

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  • WB
  • IP

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 30
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    UCP3 (D6J8K) Rabbit Monoclonal Antibody recognizes endogenous levels of total UCP3 protein. This antibody does not cross-react with UCP1 or UCP2 proteins.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly110 of human UCP3 protein.

    Background

    Uncoupling protein 3 (UCP3), a mitochondrial inner membrane transport protein, is highly expressed in skeletal muscle and activates glucose transport in muscle cells (2). UCP3 lowers the production of reactive oxygen species in mitochondria by reducing the mitochondrial inner membrane potential (3). UCP3 has been implicated in the protection against fat-induced insulin resistance in skeletal muscle (4) and fat gain induced by high-fat feeding (1).

    Alternate Names

    Mitochondrial uncoupling protein 3; Putative mitochondrial transporter UCP3; SLC25A9; Solute carrier family 25 member 9; UCP 3; UCP3; uncoupling protein 3; uncoupling protein 3 (mitochondrial, proton carrier); Uncoupling protein-3

    For Research Use Only. Not for Use in Diagnostic Procedures.
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