Cell Signaling Technology Logo - Extra Large
Trial Size Available Flag
Recombinant Flag
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

UQCRC2 (F8Y5N) Rabbit Monoclonal Antibody #99258

Filter:
  • WB
  • IP

    Product Specifications

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 48
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Simple Western™ 1:50 - 1:250
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    UQCRC2 (F8Y5N) Rabbit Monoclonal Antibody recognizes endogenous levels of total UQCRC2 protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human UQCRC2 protein.

    Background

    Ubiquinol-cytochrome c reductase complex core protein 2 (UQCRC2), also known as cytochrome b-c1 complex subunit 2, is a component of the ubiquinol-cytochrome c oxidoreductase complex (Complex III) in the mitochondrial electron transport chain (1,2). Studies show that AMPK increases UQCRC2 expression to promote mitophagy, protecting the liver against alcohol-induced injury (3). In addition, overexpression of UQCRC2 was shown to inhibit gastric cancer cell proliferation, invasion, and migration (4).

    Alternate Names

    Complex III subunit 2; Core protein II; Cytochrome b-c1 complex subunit 2, mitochondrial; cytochrome bc-1 complex core protein II; MC3DN5; QCR2; ubiquinol-cytochrome c reductase core protein 2; ubiquinol-cytochrome c reductase core protein II; Ubiquinol-cytochrome-c reductase complex core protein 2; UQCR2; UQCRC2

    For Research Use Only. Not for Use in Diagnostic Procedures.
    Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
    All other trademarks are the property of their respective owners. Visit our Trademark Information page.