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  3. VPS26A (E9S7W) Rabbit Monoclonal Antibody
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Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

VPS26A (E9S7W) Rabbit Monoclonal Antibody #99384

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  • WB

    Product Specifications

    REACTIVITY H M R Mk
    SENSITIVITY Endogenous
    MW (kDa) 38
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    VPS26A (E9S7W) Rabbit Monoclonal Antibody recognizes endogenous levels of total VPS26A protein.

    Species Reactivity:

    Human, Mouse, Rat, Monkey

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro221 of human VPS26A protein.

    Background

    Vacuolar protein sorting-associated protein 26A (VPS26A), together with VPS29 and VPS35, is part of a trimeric protein complex known as the cargo-selective complex (CSC) (1). The CSC is regarded as the core functional component of the retromer, a multimeric protein complex involved in selective transport of cargo proteins from endosomes to the trans-Golgi network or plasma membrane (2). As part of the CSC, VPS26A does not have intrinsic membrane-binding activity but relies on association with RAB7A for recruitment to the cytosolic face of the endosomal membrane (3,4). Retromer defects are associated with neurological disease, and VPS26A mutations have been linked to perturbed endosomal cargo sorting in atypical parkinsonism (5).

    Alternate Names

    FLJ12930; HB58; Hbeta58; hVPS26; PEP8A; vacuolar protein sorting 26 homolog A; vacuolar protein sorting 26 homolog A (S. pombe); Vacuolar protein sorting-associated protein 26A; Vesicle protein sorting 26A; VP26A; VPS26; VPS26 retromer complex comonent A; VPS26, retromer complex component A; VPS26A

    Database Links

    UniProt ID: O75436


    Entrez-Gene Id: 9559


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    For Research Use Only. Not for Use in Diagnostic Procedures.
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