Products /
Primary Antibodies /
Ykt6 Antibody

Ykt6 Antibody #97076

Filter:

Supporting Data

REACTIVITY	H M R
SENSITIVITY	Endogenous
MW (kDa)	22
SOURCE	Rabbit

Application Key:

WB-Western Blotting

Species Cross-Reactivity Key:

H-Human
M-Mouse
R-Rat

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

Ykt6 Antibody recognizes endogenous levels of total Ykt6 protein.

Species Reactivity:

Human, Mouse, Rat

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro133 of human Ykt6 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

Synaptobrevin-2 homolog Ykt6 is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein family. SNARE proteins represent the core membrane fusion machinery that drives membrane fusion in the cell. Ykt6 is an unusual SNARE as it lacks a transmembrane domain but uses farnesylation and palmitoylation as membrane anchors to mediate SNARE-dependent membrane fusion (1). Ykt6 plays a key role in ER-Golgi trafficking but can also facilitate other organelle transport, including intra-Golgi, endosome-Golgi, and autophagosome formation trafficking. Ykt6 is also involved in trafficking of proteins to lysosomal compartments from the Golgi under normal conditions and in response to cellular stress. α-Synuclein, a protein that accumulates and is genetically linked to Parkinson’s disease and dementia with Lewy bodies, associates with and deactivates Ykt6 (2). Deactivation of Ykt6 by α-Synuclein alters normal α-Synuclein proteostasis and may represent a cellular mechanism by which α-Synuclein accumulation occurs.

Database Links

UniProt ID: O15498

Entrez-Gene Id: 10652

Limited Uses

Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.

Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

For Research Use Only. Not For Use In Diagnostic Procedures.

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

XP is a registered trademark of Cell Signaling Technology, Inc.

All other trademarks are the property of their respective owners. Visit our Trademark Information page.