ZCCHC3 Antibody #65321
- WB
- IP
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 46 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:100 |
Storage
Protocol
Specificity / Sensitivity
ZCCHC3 Antibody recognizes endogenous levels of total ZCCHC3 protein.
Species Reactivity:
Human
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln17 of human ZCCHC3 protein. Antibodies are purified by peptide affinity chromatography.
Background
ZCCHC3 belongs to the family of CCHC-type zinc-finger proteins (1). It binds to cGAS and acts as a cGAS co-sensor in recognizing double-stranded DNA (dsDNA), therefore, playing an essential role in innate immune response to DNA virus (2). ZCCHC3 was also shown to bind dsRNA and promote the binding of dsRNA by the retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs) RIG-I and MDA5, playing a critical role in RLR-mediated innate immune response to RNA virus (3).
Limited Uses
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