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ZDHHC24 (F9U2B) Rabbit Monoclonal Antibody #46003

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  • WB
  • IP

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 25
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:100

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    ZDHHC24 (F9U2B) Rabbit Monoclonal Antibody recognizes endogenous levels of total ZDHHC24 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human ZDHHC24 protein.

    Background

    Palmitoylation, also known as S-acylation, is a posttranslational modification characterized by the reversible addition of fatty acids onto cysteine residues (1). Palmitoylation is typically carried out by a family of transmembrane enzymes known as zinc finger DHHC domain-containing (ZDHHC) proteins (2). One family member in particular, ZDHHC24, has been shown to palmitoylate mitochondrial antiviral signaling protein (MAVS), consequently activating the TBK1-IRF3-interferon (IFN) pathway and promoting antiviral immune responses (3).

    Alternate Names

    DHHC-24; Probable palmitoyltransferase ZDHHC24; ZDH24; ZDHHC24; Zinc finger DHHC domain-containing protein 24; zinc finger DHHC-type containing 24; zinc finger, DHHC domain containing 24; zinc finger, DHHC-type containing 24

    For Research Use Only. Not for Use in Diagnostic Procedures.
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