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ZIP8/SLC39A8 (E2L8E) Rabbit Monoclonal Antibody #35993

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  • WB

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 65, 130
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    ZIP8/SLC39A8 (E2L8E) Rabbit Monoclonal Antibody recognizes endogenous levels of total ZIP8/SLC39A8 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human ZIP8/SLC39A8 protein.

    Background

    Zinc transporter zinc-and iron-related protein 8 (ZIP8) is encoded by the SLC39A8 gene and is a member of the solute carrier gene (SLC) superfamily (1).  As a membrane protein, ZIP8 functions to transport manganese, cadmium, and zinc across the plasma membrane (2). Metal ions are essential elements that are required cofactors for proteins, including enzymes and transcription factors. Maintenance of proper metal ion homeostasis is required for normal mammalian tissue development and function. Mice lacking SLC39A8 reveal a critical role of ZIP8 in organogenesis in multiple tissues, including the brain and kidney, during development (3,4). Mutations in SLC39A8 are linked to autosomal-recessive forms of intellectual disability, suggesting that altered ZIP8-dependent metal ion regulation may contribute to human neuronal developmental diseases (5).

    Alternate Names

    BCG induced integral membrane protein BIGM103; BCG-induced integral membrane protein in monocyte clone 103 protein; BIGM103; CDG2N; LIV-1 subfamily of ZIP zinc transporter 6; LZT-Hs6; Metal cation symporter ZIP8; PP3105; S39A8; SLC39A8; solute carrier family 39 (metal ion transporter), member 8; solute carrier family 39 (zinc transporter), member 8; Solute carrier family 39 member 8; Zinc transporter ZIP8; ZIP-8; ZIP8; Zrt- and Irt-like protein 8

    For Research Use Only. Not for Use in Diagnostic Procedures.
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