This Cell Signaling Technology (CST) antibody is immobilized by the covalent reaction of hydrazinonicotinamide-modifed antibody with formylbenzamide-modified magnetic bead. GβL (86B8) Rabbit mAb (Magnetic Bead Conjugate) is useful for immunoprecipitation assays of GβL protein. The unconjugated GβL (86B8) Rabbit mAb #3274 reacts with human, mouse, rat, and monkey GβL protein. CST expects that GβL (86B8) Rabbit mAb (Magnetic Bead Conjugate) will also recognize GβL in these species.
Supplied in PBS Buffer (pH 7.2), 0.1% Tween® 20. Store at 4°C. Do not aliquot the antibodies.
GβL (86B8) Rabbit mAb (Magnetic Bead Conjugate) detects endogenous levels of total GβL protein.
GβL (86B8) Rabbit mAb is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln210 of human GβL.
Cell growth is a fundamental biological process whereby cells accumulate mass and increase in size. The mammalian Target of Rapamycin (mTOR) pathway regulates growth by coordinating energy and nutrient signals with growth factor-derived signals (1). mTOR is a large protein kinase with two different complexes. One complex contains mTOR, GβL, and raptor, which is a target of rapamycin. The other complex, insensitive to rapamycin, includes mTOR, GβL, and rictor (1). GβL associates with the kinase domain of mTOR and stimulates mTOR kinase activity (2). A reduction in GβL expression has been shown to decrease in vivo phosphorylation of S6K1 (2).
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Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
U.S. Patent No. 5,675,063.