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Given the limited but remarkable success of immune checkpoint blockade, recent efforts have been focused on identifying new targets for improving immunotherapy effectiveness in the immunosuppressive tumor microenvironment. One such target is T cell immunoreceptor with Ig and ITIM domains (TIGIT).
SignalStar™ is a tool for studying FFPE tissue to identify what cell types are present, their spatial location, and their functions. Learn more here.
Products and Related Resources for Adaptive Immune Response SARS-CoV-2 Research
CST offers a growing portfolio of products for the study of immune checkpoint targets in cancer, including several receptor-ligand pairs.
Streamline your oncology therapeutic development with CST recombinant monoclonal antibodies, ELISA and cellular assay kits, custom products, and services.
SignalStar™ Spatial Profiling is a revolutionary new tool for spatial biology research with fully customizable and highly-validated antibody IHC panels.
Cell behavior is a tightly regulated process where various signals work together to elicit a specific response. Unraveling these mechanisms allows us to understand how cells are regulated in a normal state.
Overview of Adhesion and Extracellular Matrix signaling networks, antibodies and related reagents, interactive pathway diagrams, and technical resources.
A scientific resource for the START protein domain containing information on structure, function, and domain binding.
A scientific resource for the GRIP protein domain containing information on structure, function, and domain binding to ARF family GTPases during vesicle trafficking.
Many cell cycle and proliferation assays exist to measure the amount and rate of cell division. Proliferation can be used as a marker for cell viability.
3D video animation of histone modifications and their effects on chromatin activation
A scientific resource for the PX protein domain containing information on structure, function, and domain binding to phospholipids.
Apoptosis is a regulated form of programmed cell death (PCD) that occurs without external influence.
Expert-reviewed interactive pathway providing a current overview of Regulation of eIF2.
Expert-reviewed interactive pathway providing a current overview of Regulation of eIF4E and p70 S6K.
Expert-reviewed interactive pathway providing a current overview of Hippo Signaling.
Immunofluorescence Protocol with Image-iT FX Signal Enhancer: easy to follow directions describing the step by step experimental procedure.
Post-translational modifications result in different protein behaviors. Western blotting can be used to assess protein PTM states using antibody pairs.
Amyloid beta is a protein fragment of the amyloid precursor protein, and is the major component of Alzheimer’s disease plaques.
Caspase-3 Activity Protocol: easy to follow directions describing the step by step experimental procedure.
Expert-reviewed interactive pathway providing a current overview of Vesicle Trafficking Presynaptic Signaling.
Immunofluorescence Protocol – Specific for Product: 2187: easy to follow directions describing the step by step experimental procedure.
Immunofluorescence Protocol for Labeling with BrdU Antibody: easy to follow directions describing the step by step experimental procedure.
Immunofluorescence Protocol with Methanol Permeabilization: easy to follow directions describing the step by step experimental procedure.
Cancer cells invade local tissue and spread to distant sites via two distinct, but similar processes known as invasion and metastasis.
Immunofluorescence Protocol with Saponin Permeabilization: easy to follow directions describing the step by step experimental procedure.
Immunofluorescence Protocol with n-Octyl-Glucoside Permeabilization: easy to follow directions describing the step by step experimental procedure.
The nuclear receptor signaling plays important roles in cell differentiation, proliferation, metabolism, and other physiological processes. Click here.
Immunofluorescence Protocol with DOTMAC Permeabilization: easy to follow directions describing the step by step experimental procedure.