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Interested in studying senescence? Understanding cell cycle arrest is critical to many fields of research, including development, aging, and cancer.
Streamline your oncology therapeutic development with CST recombinant monoclonal antibodies, ELISA and cellular assay kits, custom products, and services.
List of publications based on primary research done by the Cancer Research Group at CST (2002-2013).
A number of growth factors and cytokines can induce an Epithelial-Mesenchymal Transition (EMT) in tumor cells.
A comprehensive list of peer-reviewed publications from Cell Signaling Technology.
Identification of ALK and ROS1 fusion proteins in non-small cell lung cancer (NSCLC) at Cell Signaling Technology.
A chronological listing of case studies and peer-reviewed publications utilizing PTMScan proteomic technology developed by Cell Signaling Technology.
The Ubiquitin Ligase Table provides a comprehensive list of E3 ubiquitin ligases along with their substrates and corresponding PubMed reference(s).
Cellular senescence is stable cell cycle arrest linked to aging and cancer and other disease states, including those associated with inflammation. It is induced by DNA damage, oncogenic signaling, and telomere shortening.
Cellular senescence is defined by permanent cell cycle arrest. Senescent cells accumulate with age and contribute to normal aging and age-related disorders
Expert-reviewed interactive pathway providing a current overview of Cell Cycle G1/S Checkpoint Signaling.
Custom synthesized, isotope-labeled AQUA peptides for validating and quantifying protein markers and post-translational modifications from Cell Signaling Technology.
We have not tested our Sox2 (D6D9) XP® Rabbit mAb #3579 for cross-reactivity with other SOX family transcription factors. However, sequence alignments have been done between the antigen used to produce the Sox2 (D6D9) XP® Rabbit mAb #3579 and the B1 Sox proteins (i.e., SOX1 and SOX3, which includes SOX2) and the B2 Sox proteins (i.e., SOX14 and SOX21). Because there is no significant sequence identity between the sequences, we do not foresee any cross-reactivity with SOX1, SOX3, SOX14, or SOX21.
We believe the 48 kDa band may represent a heterodimer of β-crystallin B1 based on the following references:https://www.ncbi.nlm.nih.gov/gene/1414Dolinska MB, Sergeev YV, Chan MP, Palmer I, Wingfield PT. N-terminal extension of beta B1-crystallin: identification of a critical region that modulates protein interaction with beta A3-crystallin. Biochemistry. 2009 Oct 13;48(40):9684-95Wang KJ, Wang S, Cao NQ, Yan YB, Zhu SQ. A novel mutation in CRYBB1 associated with congenital cataract-microcornea syndrome: the p.Ser129Arg mutation destabilizes the βB1/βA3-crystallin heteromer but not the βB1-crystallin homomer. Hum Mutat. 2011 Mar;32(3):E2050-60
Products and Related Resources for Fibrosis SARS-CoV-2 Research
Products and Related Resources for Adaptive Immune Response SARS-CoV-2 Research
Products and Related Resources for Virus Detection and Innate Immune Activation SARS-CoV-2 Research
This application note can help you optimize dual staining of mouse CD8 and FoxP3 on the Leica Bond autostainer.
A list of important CD markers that includes links to PhosphoSitePlus, Uniprot, and products from Cell Signaling Technology.
Senescent cells increase in number during aging and have been implicated in the decline of organismal function over time, as well as in the progression of age-related diseases.
Drs. Cominelli and Kugathasan describe new techniques to identify and target inflammatory signaling in gastrointestinal immune cells in this webinar.
SignalStar™ is a tool for studying FFPE tissue to identify what cell types are present, their spatial location, and their functions. Learn more here.
Expert-reviewed diagram providing a current overview of the Senescence Signaling pathway with references to its role in cell cycle
Interact with this CAR-T signaling pathway to learn how the combination of extracellular and intracellular domains, including CD8, CD28, 4-1BB, OX40, or CD27, exert antitumor effects.
In response to a variety of environmental factors, cells may permanently cease proliferation and enter a state known as cellular senescence.
Products and Related Resources for Viral Entry, Replication, and Transcription SARS-CoV-2 Research
Scientists used around 30 different Cell Signaling Technology® antibodies to characterize the Ras GTPase-activating protein-binding proteins G3BP1 and G3BP2.
Cell states can be monitored using markers correlating to your process of interest. These assays and antibodies can be used to detect cell viability, senescence, proliferation, apoptosis, cytotoxicity and oxidative state.
Cellular senescence is a state of stable cell cycle arrest under which cells remain metabolically active, but no longer divide or respond to growth-promoting stimuli.