What is the 48 kDa band detected by the β-crystallin B1/crybb1 Rabbit Antibody #95666?

We believe the 48 kDa band may represent a heterodimer of β-crystallin B1 based on the following references:
https://www.ncbi.nlm.nih.gov/gene/1414
Dolinska MB, Sergeev YV, Chan MP, Palmer I, Wingfield PT. N-terminal extension of beta B1-crystallin: identification of a critical region that modulates protein interaction with beta A3-crystallin. Biochemistry. 2009 Oct 13;48(40):9684-95
Wang KJ, Wang S, Cao NQ, Yan YB, Zhu SQ. A novel mutation in CRYBB1 associated with congenital cataract-microcornea syndrome: the p.Ser129Arg mutation destabilizes the βB1/βA3-crystallin heteromer but not the βB1-crystallin homomer. Hum Mutat. 2011 Mar;32(3):E2050-60

Last updated: September 12, 2024