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Interested in studying senescence? Understanding cell cycle arrest is critical to many fields of research, including development, aging, and cancer.
Apoptosis is a type of programmed cell death that occurs normally throughout the lifespan and can also occur in response to harmful stimuli. Apoptotic cells are identified by their altered morphology, caspase activation, and the presence of damaged DNA.
The Ubiquitin Ligase Table provides a comprehensive list of E3 ubiquitin ligases along with their substrates and corresponding PubMed reference(s).
Identification of ALK and ROS1 fusion proteins in non-small cell lung cancer (NSCLC) at Cell Signaling Technology.
List of publications based on primary research done by the Cancer Research Group at CST (2002-2013).
A comprehensive list of peer-reviewed publications from Cell Signaling Technology.
A chronological listing of case studies and peer-reviewed publications utilizing PTMScan proteomic technology developed by Cell Signaling Technology.
Streamline your oncology therapeutic development with CST recombinant monoclonal antibodies, ELISA and cellular assay kits, custom products, and services.
Products and Related Resources for Virus Detection and Innate Immune Activation SARS-CoV-2 Research
Products and Related Resources for Cytokines and Inflammation SARS-CoV-2 Research
Expert-reviewed interactive pathway providing a current overview of Death Receptor Signaling.
Expert-reviewed interactive pathway providing a current overview of TLR signaling.
Information and case study data for the PTMScan Direct Ser/Thr Kinases Service, which allows for the targeted screening of a defined set of protein modification sites.
Custom synthesized, isotope-labeled AQUA peptides for validating and quantifying protein markers and post-translational modifications from Cell Signaling Technology.
We have not tested our Sox2 (D6D9) XP® Rabbit mAb #3579 for cross-reactivity with other SOX family transcription factors. However, sequence alignments have been done between the antigen used to produce the Sox2 (D6D9) XP® Rabbit mAb #3579 and the B1 Sox proteins (i.e., SOX1 and SOX3, which includes SOX2) and the B2 Sox proteins (i.e., SOX14 and SOX21). Because there is no significant sequence identity between the sequences, we do not foresee any cross-reactivity with SOX1, SOX3, SOX14, or SOX21.
Information and case study data for the PTMScan Direct Apoptosis/Autophagy Service offered by CST.
We believe the 48 kDa band may represent a heterodimer of β-crystallin B1 based on the following references:https://www.ncbi.nlm.nih.gov/gene/1414Dolinska MB, Sergeev YV, Chan MP, Palmer I, Wingfield PT. N-terminal extension of beta B1-crystallin: identification of a critical region that modulates protein interaction with beta A3-crystallin. Biochemistry. 2009 Oct 13;48(40):9684-95Wang KJ, Wang S, Cao NQ, Yan YB, Zhu SQ. A novel mutation in CRYBB1 associated with congenital cataract-microcornea syndrome: the p.Ser129Arg mutation destabilizes the βB1/βA3-crystallin heteromer but not the βB1-crystallin homomer. Hum Mutat. 2011 Mar;32(3):E2050-60
Discover the insulin signaling pathway and its role in glucose metabolism & diabetes. Learn more about insulin action here.
Explore the NFkB pathway and its impact on inflammation and immune responses. Click here to learn more about this signaling pathway.
Senescent cells increase in number during aging and have been implicated in the decline of organismal function over time, as well as in the progression of age-related diseases.
Discover the PI3K Akt pathway and its crucial role in cell growth and survival. Click here to learn more & gain insights into this important signaling cascade
Several different assays can be used by scientists to measure metabolism in a variety of contexts. These include methods to determine metabolic rates, key signaling pathways, and environmental cues.
Scientists used around 30 different Cell Signaling Technology® antibodies to characterize the Ras GTPase-activating protein-binding proteins G3BP1 and G3BP2.
A scientific resource for the CALM protein domain, also known as ANTH domain, containing information on structure, function, and binding to phospholipids.
Expert-reviewed diagram providing a current overview of the Senescence Signaling pathway with references to its role in cell cycle
Products and Related Resources for Viral Entry, Replication, and Transcription SARS-CoV-2 Research
Expert-reviewed interactive pathway providing a current overview of the Inflammasome Signaling Pathway.
Cell states can be monitored using markers correlating to your process of interest. These assays and antibodies can be used to detect cell viability, senescence, proliferation, apoptosis, cytotoxicity and oxidative state.
Cellular senescence is a state of stable cell cycle arrest under which cells remain metabolically active, but no longer divide or respond to growth-promoting stimuli.
