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AML1 and ETO can form a leukemia-associated fusion protein that migrates at approximately 94 kDa (expressed in Kasumi-1 cells). Our AML1 Antibody #4334 and AML1 (D33G6) XP Rabbit mAb #4336 detect both AML1 and the AML1-ETO fusion proteins very well. Our AML1 Antibody (Mouse Preferred) #8229 detects AML1, but only weakly detects the AML1-ETO fusion protein. Our AML1 (D4A6) Rabbit mAb (Mouse Preferred) #8529 only detects AML1. Our ETO Antibody #4498 only weakly detects the AML-ETO fusion protein compared to the other products.
The ESC and Lineage Markers diagram provides an overview of ESC differentiation along lineage-specific pathways and links to products from CST.
Find validated CST® matched antibody pairs and streamline the development of your High-Throughput ELISA-Like Immunoassays for screening.
Discover the epigenetic drivers that help drive MDS / AML cancers
Cell Signaling Technology, Inc. (CST) of Danvers, MA, announced today that it has introduced a highly specific PD-L1 rabbit monoclonal antibody (mAb).
Information and case study data for the PTMScan Direct PI3K/Akt Service offered by CST, which allows for targeted screening of 105 proteins within the Akt pathway.
Information and case study data for the PTMScan Direct Cell Cycle and DNA Damage Service offered by CST.
Discover the most important epigenetic markers that contribute to the progression of diffuse intrinsic pontine glioma (DIPG).
Discover the top epigenetic markers that you should look out for in prostate cancer research.
Information and case study data for the PTMScan Direct Tyrosine Kinases Service from Cell Signaling Technology.
Discover the key epigenetic drivers of breast cancer and the best products to target them.
Find out which epigenetic markers are important drivers in mixd lineage leukemia, or MLL.
Jak and cytokine receptor mutations found in various cancers, along with the corresponding PubMed reference(s).
Cellular senescence is stable cell cycle arrest linked to aging and cancer and other disease states, including those associated with inflammation. It is induced by DNA damage, oncogenic signaling, and telomere shortening.
Guest blogger Dr Gregory discusses research to define the epitranscriptome, including modifications that increase tRNA stability and prevent degradation.
A chronological listing of case studies and peer-reviewed publications utilizing PTMScan proteomic technology developed by Cell Signaling Technology.
The PI3K / Akt Substrates Table provides a comprehensive list of demonstrated downstream targets of Akt phosphorylation.
Learn how RNA-binding proteins influence RNA regulation and epitranscriptomics and contribute to the progression of a variety of diseases.
List of publications based on primary research done by the Cancer Research Group at CST (2002-2013).
Cell Signaling Technology, Inc. (CST) is ISO 9001:2008 certified for the design, development, and production of monoclonal antibodies (mAbs).
Kinase-disease associations table showing kinases, kinase groups, disease types, and the molecular biology basis for disease.
A comprehensive list of peer-reviewed publications from Cell Signaling Technology.
Epigenetic Drivers and Regulators of Cancer, epigenetics's role in cancer initiation & progression is critical for prevention, detection & treatment.
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We have no specific tips for using FACS-isolated cells in CUT&RUN experiments. Like a cultured cell suspension, if your isolated cells are in less than 40ul PBS, you can move directly to Concanavalin A bead binding by adding wash buffer for a total of 100ul per reaction. Otherwise, you need to either spin the cells and remove some of the PBS or add wash buffer and Concanavalin A beads proportionally based on the volume of PBS you have in your sorted cell sample. In our experience, the Concanavalin A beads do not bind to cells in the pure PBS environment.
Aug 2006, CST announced the publication of discovery research based on its patent-pending PhosphoScan® proteomics technology, which identified a mutant JAK3 tyrosine kinase as a novel driver in acute myeloid leukemia (AML).
Cell Signaling Technology, a leading provider of antibodies, kits and services, announced today that it has won two Life Science Industry Awards® for "Best Antibodies" and "Most Useful Website."
Dako and Cell Signaling Technology (CST) today announced that they have entered into a strategic partnership to supply antibodies for use in Dako-branded companion diagnostics products.
