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Information and case study data for the PTMScan Direct Tyrosine Kinases Service from Cell Signaling Technology.
Expert-reviewed interactive pathway providing a current overview of T Cell Receptor (TCR) Signaling.
Expert-reviewed interactive pathway providing a current overview of ErbB/HER Signaling.
Products and Related Resources for Adaptive Immune Response SARS-CoV-2 Research
This post explores common T cell types, their roles in modulating immune cell response, and T cell activation via interaction with cell surface receptors.
Kinase-disease associations table showing kinases, kinase groups, disease types, and the molecular biology basis for disease.
Hypoxia causes cellular stress and alters normal metabolic activity. These pathways allow cells to survive and recover during bouts of low oxygen.
What is glycolysis? Glycolysis and oxidative respiration are the two metabolic pathways used to convert biochemical energy into ATP to fuel cell function.
A novel study from the laboratory of Daniel Figeys begins to unravel the complexity of the microbiome of pediatric patients with Crohn’s disease.
Click here to read about the phospholipase C pathway and its role in cellular signaling and regulation.
Expert-reviewed diagram providing a current overview of the m6A RNA pathway with references to its role in tumor development
Explore the AMPK pathway and its role in cellular energy homeostasis. Uncover the mechanisms of energy regulation. Learn more here.
Explore the mitochondrial apoptosis pathway and its role in programmed cell death. Read more about this essential pathway here.
Even though EGR1 has a predicted size of ~58kDa, 75kDa is the correct running size. This is because EGR1 is Sumoylated, which along with other PTMs, increases the size it runs at on a western blot.
Why not take advantage of our own immune system and the best of its weaponry, the T-cells, to fight cancer? This is the basis of immunotherapy.
Unravel the HER2 signaling pathway and its role in cell growth and cancer. Explore the molecular mechanisms and signaling events. Click here.
Matthew Stokes, Ph.D., and Christopher Rose, Ph.D. introduce Cell Signaling Technology’s PTMScan® method and provide a demonstration of its applications.
Tau is a microtubule-associated protein found in neurons, and its function is to stabilize axonal microtubules. Hyperphosphorylated tau is a hallmark of several neurodegenerative diseases including Alzheimer’s disease.
TrkA is a highly glycosylated protein. Therefore, its size can differ depending on the amount of glycosylation present. Un-glycosylated TrkA is 87 KDa, so this is likely what the 90kDa band is on the blot.
Expert-reviewed diagram providing a current overview of the Mechanisms of Fibrosis pathway with references to its role in adhesion
Expert-reviewed diagram providing a current overview of the Senescence Signaling pathway with references to its role in cell cycle
Study the ubiquitin proteasome pathway and its critical role in protein degradation and cellular homeostasis. Expert reviewed pathways.
Explore the NFkB pathway and its impact on inflammation and immune responses. Click here to learn more about this signaling pathway.
Learn here about the HIF-1 signaling pathway and its impact on oxygen homeostasis and cellular adaptation. Click here.
Study the intricate Notch signaling pathway and its impact on cell fate determination and development. Click here to learn more.
Discover the insulin signaling pathway and its role in glucose metabolism & diabetes. Learn more about insulin action here.
Explore the G protein coupled receptor signaling pathway and its diverse roles in cellular communication. Read more here.
Discover the mTOR pathway and its role in cellular growth and metabolism. Click here to explore the intricacies of this vital signaling pathway.
Study the IL-6 pathway and its impact on inflammation and immune regulation. Delve into the intricacies of this signaling cascade. Click here.
