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Study the PKC pathway's role in cellular signaling and regulation. Explore the molecular mechanisms & signaling events governed by this pathway. Click.
Overview of GPCR, Calcium, cAMP Signaling Resources, interactive pathway diagrams, and other technical resources.
Information and case study data for the PTMScan Direct Ser/Thr Kinases Service, which allows for the targeted screening of a defined set of protein modification sites.
Discover the insulin signaling pathway and its role in glucose metabolism & diabetes. Learn more about insulin action here.
Study the intricate machinery of the apoptosis signaling pathway. Click here to learn more and gain insights into programmed cell death mechanisms.
Information and case study data for the PTMScan Direct Apoptosis/Autophagy Service offered by CST.
Information and case study data for the PTMScan Direct PI3K/Akt Service offered by CST, which allows for targeted screening of 105 proteins within the Akt pathway.
Products and Related Resources for Cytokines and Inflammation SARS-CoV-2 Research
A scientific resource for the C1 protein domain containing information on structure, function, and binding to phospholipids.
A scientific resource for the PB1 protein domain containing information on structure, function, and domain binding in cytoskeletal signaling proteins.
For antigenic targets where expression of the protein is very low or unknown, the use of recombinant proteins or exogenous expression in a surrogate cell line may be necessary for antibody validation.
Validation using recombinant proteins or exogenous expression in a surrogate cell line can be used for targets with low levels of protein expression.
Expert-reviewed interactive pathway providing a current overview of T Cell Receptor (TCR) Signaling.
Our Phospho-Akt (Ser473) (D9E) XP® Rabbit mAb #4060 and Phospho-Akt (Ser473) (D9W9U) Mouse mAb #12694 detect over-expressed PKC alpha and beta. Our Phospho-Akt (Ser473) (D9E) XP® Rabbit mAb #4060 also detects endogenous levels of PKC in Jurkat + CalA extract, but not in other endogenous models tested. Our Phospho-Akt (Ser473) (587F11) Mouse mAb #4051 detects over-expressed PKC alpha and beta but does not detect endogenous PKC in the models tested. Our Phospho-Akt (Ser473) (193H12) Rabbit mAb #4058 does not detect over-expressed or endogenous PKC alpha and beta.
Our Akt (pan) (C67E7) Rabbit mAb #4691 does not detect over-expressed or endogenous levels of PKC.
Learn more about commonly used chemical modulators to study cellular physiology and biology.
Kinase-disease associations table showing kinases, kinase groups, disease types, and the molecular biology basis for disease.
Our Phospho-Akt (Thr308) (C31E5E) Rabbit mAb #2965 detects over-expressed levels of PKCalpha and beta. It also detects endogenous levels of PKC in Jurkat + CalA extract and possibly weakly in other endogenous models tested. Our Phospho-Akt (Thr308) (L32A4) Mouse mAb #5106 and Phospho-Akt (Thr308) Antibody #9275 detect over-expressed levels of PKCalpha and beta, but do not detect endogenous PKC. Our Phospho-Akt (Thr308) (244F9) Rabbit mAb #4056 detects over-expressed levels of PKCalpha and beta and may also weakly detect endogenous PKC in Jurkat + CalA extract, but not in other endogenous models tested. Our Phospho-Akt (Thr308) (D25E6) XP Rabbit mAb #13038 does not detect over-expressed PKC and is the best choice of the Phospho-Akt (Thr308) antibodies if this is a concern.
Several different assays can be used by scientists to measure metabolism in a variety of contexts. These include methods to determine metabolic rates, key signaling pathways, and environmental cues.
A scientific resource for the C2 protein domain containing information on structure, function, and binding to phospholipids.
Overview of apoptosis signaling networks, antibodies and related reagents, interactive pathway diagrams, and technical resources for apoptosis research.
A demonstration of the perils of deviating from Cell Signaling Technology's recommended protocols.
Click here to read about the phospholipase C pathway and its role in cellular signaling and regulation.
Explore the G protein coupled receptor signaling pathway and its diverse roles in cellular communication. Read more here.
A scientific resource for the VHL protein domain containing information on structure, function, and domain binding to hydroxylated proline residues.
Learn about BCR signaling and how it can lead to changes in cell metabolism, gene expression, and cytoskeletal organization. Click here.
A scientific resource for the 14-3-3 protein domain containing information on structure, function, and binding to phospho-serine and phospho-threonine motifs.
Human protein kinases overview: Learn about the largest and most functionally diverse gene family, the different types and their functions. Click here.
Here’s what you should know about your target before you start searching for antibodies, and the questions to ask to avoid choosing the wrong one.
A kinome diagram showing the ACG group of protein kinases from Cell Signaling Technology.
