Do your total mTOR antibodies detect mTOR in mTORC1 and mTORC2?

mTOR is the catalytic subunit of two functionally distinct complexes, mTOR Complex 1 (mTORC1) and mTOR Complex 2 (mTORC2). mTORC1 is composed of mTOR, Raptor, mLST8/GL, PRAS40 and DEPTOR. mTORC2, on the other hand, is composed of mTOR, Rictor, GßL, and mSIN1. Our total mTOR antibodies (#2983, #2972, and #4517) recognize total mTOR kinase in both complexes.
 

Last updated: February 27, 2024