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Does the Calpain 2 Large Subunit (M-type) Antibody #2539 detect the active, inactive, and cleaved forms of calpain 2?

The Calpain 2 Large Subunit (M-type) Antibody #2539 detects both active and inactive Calpain 2, which migrate at the same size (79-80 kDa). When Calpain 2 is autoproteolytically cleaved at Ser20, it can result in a 78 kDa band. Cleavage of Calpain 2 at serine 20 does not cause it to be activated; Calpain is only activated when it is bound to calcium.

Last updated: February 27, 2024

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