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How does the specificity of the F(ab’)2 fragments differ from the corresponding full-length monoclonal antibodies?

Since the paratopes of the antibody fragments are identical to that of the corresponding full-length monoclonal antibodies, their specificity for scFv linkers remains unchanged. However, the absence of an intact Fc region eliminates non-specific interaction with human immune cells that express Fc receptors, such as monocytes, NK cells, and neutrophils.

Last updated: July 1, 2024

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