Is it possible to perform CUT&Tag on frozen cells?

Yes. CUT&Tag can be performed on frozen cell pellets, with or without fixation prior to freezing. Frozen or fixed-frozen cell pellets can be stored at -80° C for up to 6 months. In our experience, live cells generally yield better performance than frozen or fixed-frozen cell pellets, so we recommend using live cells whenever possible, unless frozen samples are required for certain situations.

Last updated: April 23, 2026