What is the light chain type of my rabbit antibody?

Rabbits only have one IgG isotype compared to four IgG isotypes in mice (IgG1, IgG2a, IgG2b and IgG3) and humans (IgG1, IgG2, IgG3 and IgG4). There are two types of rabbit light chains - κ and λ - with the κ light chain present as two different isotypes called K1 and K2. K1 is by far the most abundant isotype, representing between 70% and 90% of all light chains, whereas the remainder are usually a mixture of both K2 and λ-light chains. Therefore, most of our rabbit monoclonal antibodies have κ light chains.

Last updated: September 12, 2024