Download Pathways by Disease Area

Autoimmunity & Inflammation

• ATP-Dependent Chromatin Remodeling Complexes
• B Cell Receptor Signaling
• DNA Methylation
• Epigenetic Writers and Erasers of Histones H2A, H2B, and H4
• Epigenetic Writers and Erasers of Histone H3
• Inflammasome Signaling
• Jak/Stat Signaling: IL-6 Receptor Family
• m6A RNA Regulatory Diagram
• NF-κB Signaling
• RNA Life Cycle Diagram
• T Cell Receptor Signaling

Cardiovascular Disease

• Angiogenesis
• ATP-Dependent Chromatin Remodeling Complexes
• Autophagy Signaling
• Death Receptor Signaling
• DNA Methylation
• Glutamine Metabolism
• Epigenetic Writers and Erasers of Histones H2A, H2B, and H4
• Epigenetic Writers and Erasers of Histone H3
• Hypoxia Signaling
• Insulin Receptor Signaling
• Necrotic Cell Death
• Nuclear Receptor Signaling
• Phosphoinositide Signaling
• Regulation of Apoptosis
• Warburg Effect

Fibrosis

• ATP-Dependent Chromatin Remodeling Complexes
• Autophagy Signaling
• Contribution of Extracellular Matrix to EMT
• Contribution of Soluble Factors to EMT
• Death Receptor Signaling
• DNA Methylation
• Mechanisms of Fibrosis
• Epigenetic Writers and Erasers of Histones H2A, H2B, and H4
• Epigenetic Writers and Erasers of Histone H3
• Hippo Signaling
• Inflammasome Signaling
• Necrotic Cell Death
• Regulation of Apoptosis
• TGF-β Signaling
• Wnt/β-Catenin Signaling

Immuno-oncology

• ATP-Dependent Chromatin Remodeling Complexes
• B Cell Receptor Signaling
• CAR Signaling Networks
• DNA Methylation
• Epigenetic Writers and Erasers of Histones H2A, H2B, and H4
• Epigenetic Writers and Erasers of Histone H3
• Tumor-Infiltrating Immune Cell Marker Guide (Human)
• Tumor-Infiltrating Immune Cell Marker Guide (Mouse)
• Immune Checkpoint Signaling in the TME
• Inflammasome Signaling
• Jak/Stat Signaling: IL-6 Receptor Family
• m6A RNA Regulatory Diagram
• NF-κB Signaling
• RNA Life Cycle Diagram
• T Cell Receptor Signaling

Metabolic Disease

• ATP-Dependent Chromatin Remodeling Complexes
• Autophagy Signaling
• DNA Methylation
• Energy Metabolism
• Glutamine Metabolism
• Epigenetic Writers and Erasers of Histones H2A, H2B, and H4
• Epigenetic Writers and Erasers of Histone H3
• Hypoxia Signaling
• Insulin Receptor Signaling
• m6A RNA Regulatory Diagram
• mTOR Signaling
• Nuclear Receptor Signaling
• Phosphoinositide Signaling
• PI3 Kinase / Akt Signaling
• RNA Life Cycle Diagram
• Senescence Signaling

Neurodegeneration

• Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease
• ATP-Dependent Chromatin Remodeling Complexes
• Autophagy Signaling
• DNA Methylation
• Dopamine Signaling in Parkinson's Disease
• Energy Metabolism
• Epigenetic Writers and Erasers of Histones H2A, H2B, and H4
• Epigenetic Writers and Erasers of Histone H3
• Inflammasome Signaling
• Jak/Stat Signaling: IL-6 Receptor Family
• m6A RNA Regulatory Diagram
• mTOR Signaling
• Neuronal and Glial Cell Marker Atlas
• NF-κB Signaling
• Regulation of Apoptosis
• RNA Life Cycle Diagram
• Senescence Signaling
• TREM2
• Vesicle Trafficking Presynaptic Signaling

Cancer: Epigenetic Plasticity

• ATP-Dependent Chromatin Remodeling Complexes
• DNA Methylation
• Epigenetic Writers and Erasers of Histone H3
• Epigenetic Writers and Erasers of Histones H2A, H2B, and H4
• Histone Lysine Methylation

Cancer: Activating Invasion and Metastasis

• Adherens Junction Dynamics
• Contribution of Extracellular Matrix to EMT
• Contribution of Soluble Factors to EMT
• Hippo Signaling
• Notch Signaling
• Regulation of Actin Dynamics
• Regulation of Microtubule Dynamics
• TGF-β Signaling
• Wnt / β-Catenin Signaling

Cancer: Tumor-promoting Inflammation

• B Cell Receptor Signaling
• Inflammasome Signaling
• Jak/Stat Signaling: IL-6 Receptor Family
• NF-κB Signaling
• T Cell Receptor Signaling
• Tumor-Infiltrating Immune Cell Marker Guide (Human)
• Tumor-Infiltrating Immune Cell Marker Guide (Mouse)

Cancer: Genome Instability and Mutation

• ATP-Dependent Chromatin Remodeling Complexes
• DNA Damage Response
• DNA Methylation
• Epigenetic Writers and Erasers of Histone H3
• Epigenetic Writers and Erasers of Histones H2A, H2B, and H4
• Cell Cycle Control: G1/S Checkpoint
• Cell Cycle Control: G2/M DNA Damage Checkpoint
• Histone Lysine Methylation

Cancer: Avoiding Immune Destruction

• B Cell Receptor Signaling
• Immune Checkpoint Signaling in the TME
• T Cell Receptor Signaling
• Tumor-Infiltrating Immune Cell Marker Guide (Human)
• Tumor-Infiltrating Immune Cell Marker Guide (Mouse)

Cancer: Evading Growth Suppressors

• Cell Cycle Control: G1/S Checkpoint
• Cell Cycle Control: G2/M DNA Damage Checkpoint
• PI3 Kinase / Akt Signaling
• Regulation of Apoptosis

Cancer: Enabling Replicative Immortality

• Cell Cycle Control: G1/S Checkpoint
• Hippo Signaling
• Notch Signaling
• Senescence Signaling
• TGF-β Signaling
• Wnt / β-Catenin Signaling

Cancer: Sustaining Proliferative Signaling

• Hippo Signaling
• Insulin Receptor Signaling
• MAPK/Erk in Growth and Differentiation
• mTOR Signaling
• Notch Signaling
• Nuclear Receptor Signaling
• Phosphoinositide Signaling
• PI3 Kinase / Akt Signaling
• TGF-β Signaling
• Wnt / β-Catenin Signaling

Cancer: Inducing Angiogenesis

• Angiogenesis
• Hypoxia Signaling
• PI3 Kinase / Akt Signaling
• Tumor Angiogenesis

Cancer: Deregulating Cellular Energetics

• Energy Metabolism
• Glutamine Metabolism
• Hypoxia Signaling
• Insulin Receptor Signaling
• mTOR Signaling
• PI3 Kinase / Akt Signaling
• Senescence Signaling
• Warburg Effect

Cancer: Resisting Cell Death

• Autophagy Signaling
• Death Receptor Signaling
• Necrotic Cell Death
• Regulation of Apoptosis
• Senescence Signaling