PLK1 Antibodies

Target Information

a serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Contains two polo-box domains (PBD), which are specific phosphoserine or -threonine binding domains. Acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Plays a key role in centrosome functions and the assembly of bipolar spindles. Promotes the targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. Involved in mitosis exit and cytokinesis. Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A; creates its own docking sites on PRC1 and KIF20A by phosphorylating sites that are subsequently recognized by the PBDs. Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation. Plays a central role in G2/M transition of mitotic cell cycle. Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and MYT1. Involved in kinetochore functions and sister chromatid cohesion. Required for recovery after DNA damage checkpoint and entry into mitosis. Regulates nuclear envelope breakdown during prophase. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. Note: This description may include information from UniProtKB.

Alternate Names

cell cycle regulated protein kinase; PLK; PLK-1; PLK1; polo (Drosophia)-like kinase; polo like kinase; polo like kinase 1; Polo-like kinase 1; polo-like kinase 1 (Drosophila); Serine/threonine-protein kinase 13; Serine/threonine-protein kinase PLK1; STPK13