CXCL10 Antibodies

Target Information

Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation. Activation of the CXCL10/CXCR3 axis plays also an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization. Belongs to the intercrine alpha (chemokine CxC) family. Mainly secreted by monocytes, endothelial cells as well as fibroblasts. Expressed by epithelial cells in thymus (PubMed:11157474). Microglial cells produce CXCL10 in response to viral stimulation (PubMed:12663757). Note: This description may include information from UniProtKB.

Alternate Names

10 kDa interferon gamma-induced protein; C-X-C motif chemokine 10; C-X-C motif chemokine ligand 10; C7; chemokine (C-X-C motif) ligand 10; CRG-; CRG-2; crg-2; Crg2; CXCL10; Cxcl10; CXCL10(1-73); CXL10; gamma IP10; Gamma-IP10; gIP-; gIP-10; Ifi; IFI10; Ifi10; INP10; Inp10; interferon activated gene 10; Interferon-gamma induced protein CRG-2; interferon-gamma-induced protein CRG-2; interferon-inducible cytokine IP-10; IP-; IP-10; IP10; mob-; mob-1; protein 10 from interferon (gamma)-induced cell line; Scyb1; SCYB10; Scyb10; small inducible cytokine B subfamily (Cys-X-Cys), member 10; small inducible cytokine subfamily B (Cys-X-Cys), member 10; Small-inducible cytokine B10