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38-58 Rabbit

Product Usage Information

Storage: Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

Basigin/EMMPRIN Antibody recognizes endogenous levels of total Basigin/EMMPRIN protein. This antibody may cross-react with a protein of unknown origin at ~80 kDa in some cell lines.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val226 of human Basigin/EMMPRIN protein. Antibodies are purified by protein A and peptide affinity chromatography.

Basigin (EMMPRIN, CD147) is a type I integral membrane receptor protein belonging to the immunoglobulin superfamily (1). Basigin is a glycosylated protein with four known isoforms, of which isoform 2 is the most abundantly expressed (2). Multiple functions have been ascribed to Basigin; foremost among these is stimulating the secretion of extracellular matrix metalloproteinases by adjacent fibroblasts, a function which has been implicated in promoting tumor progression (2-4). Research studies have shown that Basigin is overexpressed by many tumor cells, and its expression level may correlate with tumor malignancy (5,6). A recent study identified the BASIGIN gene as a regulatory target of Slug, suggesting a role for Basigin in the process of epithelial-mesenchymal transition (7). Basigin has also been identified as a marker for a subset of highly suppressive regulatory T cells (8), and as an obligate receptor for the malarial parasite Plasmodium falciparum on human erythrocytes (9).

1.  Biswas, C. et al. (1995) Cancer Res 55, 434-9.

2.  Liao, C.G. et al. (2011) Mol Cell Biol 31, 2591-604.

3.  Sweeny, L. et al. (2012) Exp Cell Res 318, 1788-98.

4.  Lescaille, G. et al. (2012) BMC Cancer 12, 115.

5.  Piao, S. et al. (2012) J Cancer Res Clin Oncol 138, 627-35.

6.  Bi, X.C. et al. (2011) Clin Invest Med 34, E358.

7.  Wu, J. et al. (2011) Oncogene 30, 4410-27.

8.  Solstad, T. et al. (2011) Blood 118, 5141-51.

9.  Crosnier, C. et al. (2011) Nature 480, 534-7.

Entrez-Gene Id 682
Swiss-Prot Acc. P35613

For Research Use Only. Not For Use In Diagnostic Procedures.
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Basigin/EMMPRIN Antibody