Basigin/EMMPRIN (E1S1V) Rabbit mAb #13287
- WB
- IHC
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 38-58 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IHC-Immunohistochemistry
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunohistochemistry (Paraffin) | 1:200 - 1:800 |
Storage
For a carrier free (BSA and azide free) version of this product see product #95203.
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala254 of human EMMPRIN protein.
Background
Basigin (EMMPRIN, CD147) is a type I integral membrane receptor protein belonging to the immunoglobulin superfamily (1). Basigin is a glycosylated protein with four known isoforms, of which isoform 2 is the most abundantly expressed (2). Multiple functions have been ascribed to Basigin; foremost among these is stimulating the secretion of extracellular matrix metalloproteinases by adjacent fibroblasts, a function which has been implicated in promoting tumor progression (2-4). Research studies have shown that Basigin is overexpressed by many tumor cells, and its expression level may correlate with tumor malignancy (5,6). A recent study identified the BASIGIN gene as a regulatory target of Slug, suggesting a role for Basigin in the process of epithelial-mesenchymal transition (7). Basigin has also been identified as a marker for a subset of highly suppressive regulatory T cells (8), and as an obligate receptor for the malarial parasite Plasmodium falciparum on human erythrocytes (9).
- Biswas, C. et al. (1995) Cancer Res 55, 434-9.
- Liao, C.G. et al. (2011) Mol Cell Biol 31, 2591-604.
- Sweeny, L. et al. (2012) Exp Cell Res 318, 1788-98.
- Lescaille, G. et al. (2012) BMC Cancer 12, 115.
- Piao, S. et al. (2012) J Cancer Res Clin Oncol 138, 627-35.
- Bi, X.C. et al. (2011) Clin Invest Med 34, E358.
- Wu, J. et al. (2011) Oncogene 30, 4410-27.
- Solstad, T. et al. (2011) Blood 118, 5141-51.
- Crosnier, C. et al. (2011) Nature 480, 534-7.
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