Cat. # | Size | Qty. | Price |
---|---|---|---|
9868T | 1 Kit (6 x 20 microliters) |
|
Product Includes | Quantity | Applications | Reactivity | MW(kDa) | Isotype |
---|---|---|---|---|---|
cdc2 (POH1) Mouse mAb 9116 | 20 µl |
|
H Mk | 34 | Mouse IgG2a |
CDK2 (78B2) Rabbit mAb 2546 | 20 µl |
|
H M R Mk | 33 | Rabbit |
CDK4 (D9G3E) Rabbit mAb 12790 | 20 µl |
|
H Mk | 30 | Rabbit IgG |
CDK6 (D4S8S) Rabbit mAb 13331 | 20 µl |
|
H Mk | 36 | Rabbit IgG |
CDK7 (MO1) Mouse mAb 2916 | 20 µl |
|
H R | 40 | Mouse IgG2b |
CDK9 (C12F7) Rabbit mAb 2316 | 20 µl |
|
H M R Hm Mk B Dg | 42, 55 | Rabbit |
Anti-rabbit IgG, HRP-linked Antibody 7074 | 100 µl |
|
Goat | ||
Anti-mouse IgG, HRP-linked Antibody 7076 | 100 µl |
|
Horse |
Product Information
Monoclonal antibody is produced by immunizing animals with a recombinant human cdc2 fusion protein, synthetic peptides corresponding to residues of human CDK2 and recombinant human CDK7, and residues near the carboxy terminus of human CDK4, human CDK6, and human CDK9 proteins.
Cyclin-dependent kinases (CDKs) are the core effectors of cell cycle progression. CDK activity is regulated through association with their cyclin partners and cyclin-dependent kinase inhibitors (CKIs) as well as by activating and inhibitory phosphorylation events. Inhibition is mediated by Wee1 and Myt1 kinases that target residues at the amino terminus of CDK1 (1,2). Dephosphorylation of these residues by cdc25 phosphatase leads to activation of CDK kinase activity (3). The CDK7/cyclinH complex is the ubiquitous mammalian CDK-activating kinase (CAK) that phosphorylates a conserved threonine residue in the T-loop domain of CDKs. The carboxy-terminal domain of RNA polymerase II is also a target of CAK as well as CDK9/cyclinT (4,5). CDK4/6 associate with cyclinD and phosphorylate retinoblastoma protein and initiate progression through the restriction point in G1 (6). CDK2 associates with cyclinE in early S phase and cyclinA later in G2. CDK1/cyclinB regulates the initiation of mitotic events (7).
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