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2071
Mili Antibody
Primary Antibodies
Polyclonal Antibody

Mili Antibody #2071

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# Product Name Application Reactivity
  • WB
  • IP
  • IHC
  • IF
M XP
No image available

Supporting Data

REACTIVITY
SENSITIVITY
MW (kDa) 110
SOURCE Rabbit

Application Key:

  • W-Western
  • IP-Immunoprecipitation
  • IHC-Immunohistochemistry
  • ChIP-Chromatin Immunoprecipitation
  • IF-Immunofluorescence
  • F-Flow Cytometry
  • E-P-ELISA-Peptide

Species Cross-Reactivity Key:

  • H-Human
  • M-Mouse
  • R-Rat
  • Hm-Hamster
  • Mk-Monkey
  • Mi-Mink
  • C-Chicken
  • Dm-D. melanogaster
  • X-Xenopus
  • Z-Zebrafish
  • B-Bovine
  • Dg-Dog
  • Pg-Pig
  • Sc-S. cerevisiae
  • Ce-C. elegans
  • Hr-Horse
  • All-All Species Expected

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

Mili Antibody detects endogenous levels of total Mili protein.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of mouse Mili. Antibodies are purified by protein A and peptide affinity chromatography.

Background

The Drosophila piwi gene was identified as being required for the self-renewal of germ-line stem cells (1). Piwi homologs are well conserved among various species including Arabidopsis, C. elegans, and human (1). Miwi and Mili proteins are both mouse homologs of Piwi and contain a C-terminal Piwi domain (2). Miwi and Mili bind to Piwi-interacting RNAs (piRNAs) in male germ cells and are essential for spermatogenesis in mouse (3-5).

  1. Cox, D.N. et al. (1998) Genes Dev 12, 3715-27.
  2. Kuramochi-Miyagawa, S. et al. (2001) Mech Dev 108, 121-33.
  3. Aravin, A. et al. (2006) Nature 442, 203-7.
  4. Grivna, S.T. et al. (2006) Proc Natl Acad Sci USA 103, 13415-20.
  5. Grivna, S.T. et al. (2006) Genes Dev 20, 1709-14.

Pathways & Proteins

Explore pathways + proteins related to this product.

Limited Uses

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For Research Use Only. Not For Use In Diagnostic Procedures.
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