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  3. Neurexin-3 (E7K3G) Rabbit Monoclonal Antibody (BSA and Azide Free)
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Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

Neurexin-3 (E7K3G) Rabbit Monoclonal Antibody (BSA and Azide Free) #25312

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  • WB

    Product Specifications

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 180
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    This product is the carrier free version of product #48004. All data were generated using the same antibody clone in the standard formulation which contains BSA and glycerol.

    This formulation is ideal for use with technologies requiring specialized or custom antibody labeling, including fluorophores, metals, lanthanides, and oligonucleotides. It is not recommended for ChIP, ChIP-seq, CUT&RUN or CUT&Tag assays. If you require a carrier free formulation for chromatin profiling, please contact us. Optimal dilutions/concentrations should be determined by the end user.

    BSA and Azide Free antibodies are quality control tested by size exclusion chromatography (SEC) to determine antibody integrity.

    Formulation

    Supplied in 1X PBS (10 mM Na2HPO4, 3 mM KCl, 2 mM KH2PO4, and 140 mM NaCl (pH 7.8)). BSA and Azide Free.

    For standard formulation of this product see product #48004

    Storage

    Store at -20°C. This product will freeze at -20°C so it is recommended to aliquot into single-use vials to avoid multiple freeze/thaw cycles. A slight precipitate may be present and can be dissolved by gently vortexing. This will not interfere with antibody performance.

    Specificity / Sensitivity

    Neurexin-3 (E7K3G) Rabbit Monoclonal Antibody (BSA and Azide Free) recognizes endogenous levels of total Neurexin-3 protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala627 of human Neurexin-3 protein.

    Background

    Neurexins are a highly polymorphic cell surface protein family, containing single transmembrane regions and extracellular domains with repeated sequences similar to laminin A, slit, and agrin, proteins that are implicated in axon guidance and synaptogenesis (1,2). The family includes Neurexin-1, -2, and -3 (NRXN1, NRXN2, and NRXN3). Each member of the Neurexin family undergoes alternative splicing, resulting in α- and β-forms of Neurexin. α-neurexins contain six laminin/neurexin/sex (LNS)-hormone-binding globulin domains. β-neurexins are transcribed from an internal promoter of their respective genes. They are composed of an N-terminal β-neurexin-specific sequence that splices into the α-neurexin sequence LNS6 domain N-terminal, generating what is effectively an N-terminally truncated α-neurexin with a short N-terminal β-neurexin motif. γ-neurexins are only transcribed from the NRXN1 gene and splice into the NRXN1α and NRXN1β sequence of what encodes the LNS6 domain C-terminal (3).

    Alternate Names

    C14orf60; KIAA0743; MGC176711; neurexin 3; neurexin III; Neurexin III-alpha; neurexin III-beta; Neurexin-3; Neurexin-3-alpha; neurexin-3-beta; NRX3A; NRXN3

    Database Links

    UniProt ID: Q9Y4C0


    Entrez-Gene Id: 9369


    Limited Uses

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    For Research Use Only. Not for Use in Diagnostic Procedures.
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