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56511
Tau Mouse Model Neuronal Viability IF Sampler Kit
Primary Antibodies
Antibody Sampler Kit

Tau Mouse Model Neuronal Viability IF Sampler Kit #56511

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Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 1

Confocal immunofluorescent analysis of mouse medulla oblangata using Phospho-Tau (Thr205) (E7D3E) Rabbit mAb (green). Blue = DAPI #4083 (fluorescent DNA dye).

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 2

Western blot analysis of normal mouse brain and Tau KO (-/-) mouse brain with Phospho-Tau (Thr205) (E7D3E) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower). Tau-KO mouse brain tissue was kindly provided by Dr. Dominic Walsh at Brigham and Women's Hospital and Harvard Medical School.

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 3

Immunohistochemical analysis of paraffin-embedded Alzheimer's brain, using Tau (Tau46) Mouse mAb.

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 4

Western blot analysis of normal mouse brain and Tau KO (-/-) mouse brain with Tau (Tau46) Mouse mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower). Tau-KO mouse brain tissue was kindly provided by Dr. Dominic Walsh at Brigham and Women's Hospital and Harvard Medical School.

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 5

Confocal immunofluorescent analysis of mouse hippocampus (left), cortex (middle), and cerebellum (right) using NeuN (D4G4O) XP® Rabbit mAb (green). Actin filaments were labeled with DyLight™ 554 Phalloidin #13054 (red). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye).

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 6

Confocal immunofluorescent analysis of mouse brain (left) and mouse retina (right) using Synaptophysin (7H12) Mouse mAb (IF Formulated) (green) and CNPase (D83E10) XP® Rabbit mAb (Alexa Fluor® 555 Conjugate) #5715 (red, left). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye).

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 7

Confocal immunofluorescent analysis of rat cerebellum and retina using PSD95 (D27E11) XP® Rabbit mAb (red) and Neurofilament-L (DA2) Mouse mAb #2835 (green). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye).

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 8

Flow cytometric analysis of Jurkat cells, untreated (blue) or treated with etoposide #2200 (green), using Cleaved Caspase-3 (Asp175) Antibody compared to a nonspecific negative control antibody (red).

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 9

Flow cytometric analysis of serum-starved Neuro-2a cells, untreated (blue) or treated with Staurosporine #9953 (1 μM, 3 hr; green), using Cleaved PARP (Asp214) (D6X6X) Rabbit mAb (Rodent Specific) (solid lines) or concentration-matched Rabbit (DA1E) mAb IgG XP® Isotype Control #3900 (dashed lines). Anti-rabbit IgG (H+L), F(ab')2 Fragment (Alexa Fluor® 488 Conjugate) #4412 was used as a secondary antibody.

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 10

Confocal immunofluorescent analysis of mouse Tg2576 brain, which overexpresses mutant human APP695. Sections were labeled with GFAP (E6N9L) Mouse mAb (green, mouse IgG2a), β-Amyloid (D3D2N) Mouse mAb #15126 (red, mouse IgG1), and HS1 (D5A9) XP® Rabbit mAb (Rodent Specific) #3892 (magenta, rabbit IgG). Samples were mounted in ProLong® Gold Antifade Reagent with DAPI #8961 (blue).

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 11

Flow cytometric analysis of NIH/3T3 cells (red) and 32D cells (blue), using HS1 (D5A9) XP® Rabbit mAb (Rodent Specific).

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 12

Confocal immunofluorescent analysis of dentate gyrus in wild-type mouse brain using Phospho-Tau (Thr205) (E7D3E) Rabbit mAb (green). Antibody was pre-incubated with a non-phospho-Tau peptide (left), a phospho-Tau (Thr205) peptide (center), or without peptide (right) to confirm phospho-specificity. Samples were mounted in ProLong® Gold Antifade Reagent with DAPI #8961 (blue).

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 13

Western blot analysis of extracts from mouse brain, untreated (-) or phosphatase-treated (+), and rat brain using Phospho-Tau (Thr205) (E7D3E) Rabbit mAb (upper) and Tau (D1M9X) Rabbit mAb #46687 (lower).

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 14

Western blot analysis of extracts from mouse and rat brain, using Tau (Tau46) Mouse mAb.

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 15

Immunohistochemical analysis of paraffin-embedded mouse cerebellum using NeuN (D4G4O) XP® Rabbit mAb.

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 16

Western blot analysis of extracts from human cerebellum and rat brain using PSD95 (D27E11) XP® Rabbit mAb.

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 17

Confocal immunofluorescent images of HT-29 cells, untreated (left) or Staurosporine #9953 treated (right), labeled with Cleaved Caspase-3 (Asp175) Antibody (green). Actin filaments have been labeled with Alexa Fluor® 555 phalloidin #8953 (red). Blue pseudocolor = DRAQ5® (fluorescent DNA dye).

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 18

Flow cytometric analysis of serum-starved H-4-II-E cells, untreated (blue) or treated with Staurosporine #9953 (1 μM, 3 hr; green), using Cleaved PARP (Asp214) (D6X6X) Rabbit mAb (Rodent Specific) (solid lines) or concentration-matched Rabbit (DA1E) mAb IgG XP® Isotype Control #3900 (dashed lines). Anti-rabbit IgG (H+L), F(ab')2 Fragment (Alexa Fluor® 488 Conjugate) #4412 was used as a secondary antibody.

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 19

Immunoprecipitation of GFAP protein from mouse brain tissue extracts. Lane 1 is 10% input, lane 2 is Mouse (E5Y6Q) mAb IgG2a Isotype Control #61656, and lane 3 is GFAP (E6N9L) Mouse mAb. Western blot analysis was performed GFAP (E6N9L) Mouse mAb.

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 20

Confocal immunofluorescent analysis of mouse Tg2576 brain which overexpresses mutant human APP695. Sections were first labeled with HS1 (D5A9) XP® Rabbit mAb (Rodent Specific) (green) and APP/β-Amyloid (NAB228) Mouse mAb #2450 (yellow). After blocking free secondary binding sites with Mouse (G3A1) mAb IgG1 Isotype Control #5415, sections were incubated with GFAP (GA5) Mouse mAb (Alexa Fluor® 647 Conjugate) #3657 (red). Nuclei were labeled with Hoechst 33342 #4082 (blue).

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 21

Immunohistochemical analysis of paraffin-embedded human Alzheimer's disease brain using Phospho-Tau (Thr205) (E7D3E) Rabbit mAb in the presence of non-phospho-Tau (Thr205) peptide (left) or phospho-Tau (Thr205) peptide (right).

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 22

Immunohistochemical analysis of paraffin-embedded mouse colon (myenteric plexus) using NeuN (D4G4O) XP® Rabbit mAb.

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 23

Confocal immunofluorescent analysis of Neuro-2a cells, untreated (left, negative) or treated with Staurosporine #9953 (1 μM, 3 hr; right, positive), using Cleaved PARP (Asp214) (D6X6X) Rabbit mAb (Rodent Specific) (green). Actin filaments were labeled with DyLight™ 554 Phalloidin #13054 (red). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye).

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 24

Western blot analysis of extracts from various tissues and cell lines using GFAP (E6N9L) Mouse mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower).

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 25

Confocal immunofluorescent analysis of 32D cells (left) and C2C12 cells (right), using HS1 (D5A9) XP® Rabbit mAb (Rodent Specific) (green). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye).

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 26

Immunohistochemical analysis of paraffin-embedded mouse brain using Phospho-Tau (Thr205) (E7D3E) Rabbit mAb.

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 27

Immunohistochemical analysis of paraffin-embedded human glioblastoma multiform using NeuN (D4G4O) XP® Rabbit mAb.

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 28

Immunohistochemical analysis of paraffin-embedded human tonsil, showing cytoplasmic and perinuclear localization in apoptotic cells (low and high magnification), using Cleaved Caspase-3 (Asp175) Antibody.

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 29

Immunohistochemical analysis of paraffin-embedded 3T3 cell pellet, untreated (left, negative) or treated with Staurosporine #9953 (right, positive), using Cleaved PARP (Asp214)(D6X6X) mAb (Rodent Specific).

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 30

Western blot analysis of extracts from mouse brain using GFAP (E6N9L) Mouse mAb as the primary antibody. Various anti-mouse isotype specific antibodies (upper) and Anti-mouse IgG, HRP-linked Antibody #7076 (lower) were used as secondary antibodies.

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 31

Immunohistochemical analysis of paraffin-embedded mouse spleen using HS1 (D5A9) XP® Rabbit mAb (Rodent Specific).

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 32

Immunohistochemical analysis of paraffin-embedded mouse small intestine using Phospho-Tau (Thr205) (E7D3E) Rabbit mAb.

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 33

Western blot analysis of extracts from mouse brain, C2C12 cells, and rat brain using NeuN (D4G4O) XP® Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 34

Immunohistochemical analysis using Cleaved caspase-3 (Asp175) antibody on SignalSlide™ Cleaved Caspase-3 IHC controls #8104 (paraffin-embedded Jurkat cells, untreated (left) or etoposide-treated (right)).

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 35

Immunohistochemical analysis of paraffin-embedded E14 rat embryo using Cleaved PARP (Asp214)(D6X6X) mAb (Rodent Specific).

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 36

Immunohistochemical analysis of paraffin-embedded LL2 syngeneic tumor using HS1 (D5A9) XP® Rabbit mAb (Rodent Specific).

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 37

Immunoprecipitation of Phospho-Tau (Thr205) from mouse brain lysates. Lane 1 mouse brain lysate immunoprecipitation, lane 2 is Rabbit (DA1E) mAb IgG XP® Isotype Control #3900, lanes 3, 4, and 5 represent three dilutions of the immunoprecipitation of mouse brain lysates at 1:50, 1:100, 1:200 respectively, and lane 6 is mouse brain lysate. Western blot analysis was performed using Phospho-Tau (Thr205) (E7D3E) Rabbit mAb.

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 38

Immunohistochemical analysis of paraffin-embedded mouse embryo, using Cleaved Caspase-3 (Asp175) Antibody preincubated with control peptide (left) or Cleaved Caspase-3 (Asp175) Blocking Peptide #1050 (right).

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 39

Immunohistochemical analysis of paraffin-embedded H-4-II-E cell pellet, untreated (left, negative) or treated with Staurosporine #9953 (right, positive), using Cleaved PARP (Asp214)(D6X6X) mAb (Rodent Specific).

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 40

Western blot analysis of cell extracts from Baf3, 32D, and mouse spleen using HS1 (D5A9) XP® Rabbit mAb (Rodent Specific).

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 41

Western blot analysis of extracts from HeLa, NIH/3T3 and C6 cells untreated, staurosporine-treated (3hrs, 1 µM in vivo) or cytochrome c-treated (1hr, 0.25 mg/ml in vitro), using Caspase-3 Antibody #9662 (upper) or Cleaved Caspase-3 (Asp175) Antibody (lower).

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 42

Immunohistochemical analysis of paraffin-embedded mouse ovary using Cleaved PARP (Asp214)(D6X6X) mAb (Rodent Specific).

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 43

Immunohistochemical analysis of paraffin-embedded mouse spleen using Cleaved PARP (Asp214)(D6X6X) mAb (Rodent Specific).

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 44

Immunoprecipitation of Cleaved PARP (Asp214) from Neuro-2a cell extracts treated with Staurosporine #9953 (1 μM, 3 hr). Lane 1 is 10% input, lane 2 is Rabbit (DA1E) mAb IgG XP® Isotype Control #3900, and lane 3 is Cleaved PARP (Asp214) (D6X6X) Rabbit mAb (Rodent Specific). Western blot was perform using Cleaved PARP (Asp214) (D6X6X) Rabbit mAb (Rodent Specific). Anti-rabbit IgG, HRP-linked Antibody #7074 was used as a secondary antibody.

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 45

Western blot analysis of extracts from serum-starved Neuro-2a cells, untreated (-) or treated with Staurosporine #9953 (1 μM, 3 hr), using Cleaved PARP (Asp214) (D6X6X) Rabbit mAb (Rodent Specific) (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower).

Tau Mouse Model Neuronal Viability IF Sampler Kit: Image 46

Western blot analysis of extracts from serum-starved H-4-II-E cells, untreated (-) or treated with Staurosporine #9953 (1 μM, 6 hr; +), using Cleaved PARP (Asp214) (D6X6X) Rabbit mAb (Rodent Specific) (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower).

To Purchase # 56511T
Product # Size Price
56511T
1 Kit  (9 x 20 µl) $ 609

Product Includes Quantity Applications Reactivity MW(kDa) Isotype
Phospho-Tau (Thr205) (E7D3E) Rabbit mAb 49561 20 µl
  • WB
  • IP
  • IHC
  • IF
H M R 50-80 Rabbit IgG
Tau (Tau46) Mouse mAb 4019 20 µl
  • WB
  • IHC
H M R 50 to 80 Mouse IgG1
NeuN (D4G4O) XP® Rabbit mAb 24307 20 µl
  • WB
  • IHC
  • IF
H M R 46-55 Rabbit IgG
Synaptophysin (7H12) Mouse mAb (IF Formulated) 9020 20 µl
  • IF
H M R Mouse IgG1
PSD95 (D27E11) XP® Rabbit mAb 3450 20 µl
  • WB
  • IF
H M R 95 Rabbit IgG
Cleaved Caspase-3 (Asp175) Antibody 9661 20 µl
  • WB
  • IP
  • IHC
  • IF
  • F
H M R Mk 17, 19 Rabbit 
Cleaved PARP (Asp214) (D6X6X) Rabbit mAb (Rodent Specific) 94885 20 µl
  • WB
  • IP
  • IHC
  • IF
  • F
M R 89 Rabbit IgG
GFAP (E6N9L) Mouse mAb 34001 20 µl
  • WB
  • IP
  • IF
H M R 50 Mouse IgG2a
HS1 (D5A9) XP® Rabbit mAb (Rodent Specific) 3892 20 µl
  • WB
  • IP
  • IHC
  • IF
  • F
M R 80 Rabbit IgG

Product Description

The Tau Mouse Model Neuronal Viability IF Sampler Kit provides an economical means of detecting proteins to confirm neuronal viability and surrounding astrocytes and microglia in mouse models by immunofluorescence.

Specificity / Sensitivity

Each antibody in the Tau Mouse Model Neuronal Viability IF Sampler Kit detects endogenous levels of its target protein. Tau (Tau46) Mouse mAb detects endogenous levels of total tau protein and also cross-reacts with MAP2 at 280 kDa. Tau (Tau46) Mouse mAb is predicted to detect all six isoforms of tau based on the amino acid sequence. Phospho-Tau (Thr205) (E7D3E) Rabbit mAb recognizes endogenous levels of tau protein only when phosphorylated at Thr205. Cleaved PARP (Asp214) (D6X6X) Rabbit mAb (Rodent Specific) recognizes endogenous levels of the large fragment (89 kDa) of rodent PARP protein only when cleaved at Asp214. HS1 (D5A9) XP® Rabbit mAb (Rodent Specific) does not recognize human HS1 protein. HS1 has a calculated size of 54 kDa, but has an apparent molecular weight of 80 kDa on SDS-PAGE gels. Cleaved Caspase-3 (Asp175) Antibody detects endogenous levels of the large fragment (17/19 kDa) of activated caspase-3 resulting from cleavage adjacent to Asp175. This antibody does not recognize full length caspase-3 or other cleaved caspases. This antibody detects non-specific caspase substrates by western blot. Non-specific labeling may be observed by immunofluorescence in specific sub-types of healthy cells in fixed-frozen tissues (e.g. pancreatic alpha-cells). Nuclear background may be observed in rat and monkey samples.

Source / Purification

Monoclonal and polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln53 of human PSD95, Asp214 of rodent PARP1, Leu310 of mouse HS1, amino-terminal residues adjacent to Asp175 of human caspase-3, a phosphopeptide surrounding Thr205 of human tau, recombinant protein specific to the carboxy terminus of human SYP and the amino terminus of human NeuN, native GFAP purified from pig spinal cord, and native bovine tau and the epitope maps to the carboxy-terminus of the protein.

Background

Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Neurofibrillary tangles are a major pathological hallmark of Alzheimer's disease; these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau, including phosphorylation of tau at Thr205 (1,2). Research studies have shown that inclusions of tau are found in a number of other neurodegenerative diseases, collectively known as tauopathies (1,3). Neuronal nuclei (NeuN, Fox-3, RBFOX3) is a nuclear protein expressed in most post-mitotic neurons of the central and peripheral nervous systems. NeuN is not detected in Purkinje cells, sympathetic ganglion cells, Cajal-Retzius cells, INL retinal cells, inferior olivary, or dentate nucleus neurons (4). Glial fibrillary acidic protein (GFAP) is the main intermediate filament in mature brain astroglial and radial glial cells. GFAP plays an important role in modulating astroglial motility and shape (5). HS1 is a protein kinase substrate that is expressed only in tissues and cells of hematopoietic origin (6). Previous work identifying markers of specific brain cell types using RNA-seq has shown HS1 to be a useful and specific tool to study microglia (7). Synaptophysin (SYP) is a neuronal synaptic vesicle glycoprotein that occurs in presynaptic vesicles of neurons (8). Postsynaptic density protein 95 (PSD95) is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. PSD95 is a scaffolding protein involved in the assembly and function of the postsynaptic density complex (9,10). Caspase-3 (CPP-32, Apoptain, Yama, SCA-1) is a critical executioner of apoptosis, as it is either partially or totally responsible for the proteolytic cleavage of many key proteins, including nuclear enzyme poly (ADP-ribose) polymerase (PARP) (11). PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress (12). PARP helps cells to maintain their viability; cleavage of PARP facilitates cellular disassembly and serves as a marker of cells undergoing apoptosis (13).

  1. Johnson, G.V. and Stoothoff, W.H. (2004) J Cell Sci 117, 5721-9.
  2. Wang, J. et al. (2000) Zhongguo Yi Xue Ke Xue Yuan Xue Bao 22, 120-3.
  3. Bramblett, G.T. et al. (1993) Neuron 10, 1089-99.
  4. Mullen, R.J. et al. (1992) Development 116, 201-11.
  5. Eng, L.F. et al. (2000) Neurochem Res 25, 1439-51.
  6. Kitamura, D. et al. (1995) Biochem Biophys Res Commun 208, 1137-46.
  7. Zhang, Y. et al. (2014) J Neurosci 34, 11929-47.
  8. Wiedenmann, B. et al. (1986) Proc Natl Acad Sci U S A 83, 3500-4.
  9. Cao, J. et al. (2005) J Cell Biol 168, 117-26.
  10. Chetkovich, D.M. et al. (2002) J Neurosci 22, 6415-25.
  11. Fernandes-Alnemri, T. et al. (1994) J Biol Chem 269, 30761-4.
  12. Satoh, M.S. and Lindahl, T. (1992) Nature 356, 356-358.
  13. Oliver, F.J. et al. (1998) J. Biol. Chem. 273, 33533-33539.

Pathways & Proteins

Explore pathways + proteins related to this product.

Limited Uses

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Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST's products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST's Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

For Research Use Only. Not For Use In Diagnostic Procedures.
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