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Interested in studying senescence? Understanding cell cycle arrest is critical to many fields of research, including development, aging, and cancer.
Loading controls are essential to ensure data reliability in your western blot. Learn about the three main considerations for loading control selection.
We have not tested our Sox2 (D6D9) XP® Rabbit mAb #3579 for cross-reactivity with other SOX family transcription factors. However, sequence alignments have been done between the antigen used to produce the Sox2 (D6D9) XP® Rabbit mAb #3579 and the B1 Sox proteins (i.e., SOX1 and SOX3, which includes SOX2) and the B2 Sox proteins (i.e., SOX14 and SOX21). Because there is no significant sequence identity between the sequences, we do not foresee any cross-reactivity with SOX1, SOX3, SOX14, or SOX21.
Information and case study data for the PTMScan Direct PI3K/Akt Service offered by CST, which allows for targeted screening of 105 proteins within the Akt pathway.
Organelle markers for immunofluorescence analysis from CST Cell Signaling Technology
An interactive 3D molecular model depicting the cellular landscape of a nucleus and its various protein subsets including DNA Damage, Replication, Transcription, etc.
Expert-reviewed interactive pathway providing a current overview of angiogenesis pathways and links to products by Cell Signaling Technology.
Cellular senescence is stable cell cycle arrest linked to aging and cancer and other disease states, including those associated with inflammation. It is induced by DNA damage, oncogenic signaling, and telomere shortening.
It was too difficult for scientists to uncover the peptides for which they enriched, so scientists from the Broad Institute and CST® created a new method.
Expert-reviewed interactive signaling pathways providing current overviews of the regulation of actin and microtubule dynamics, as well as links to products from CST.
Expert-reviewed diagram providing a current overview of the Senescence Signaling pathway with references to its role in cell cycle
Cellular senescence is a state of stable cell cycle arrest under which cells remain metabolically active, but no longer divide or respond to growth-promoting stimuli.
Senescent cells increase in number during aging and have been implicated in the decline of organismal function over time, as well as in the progression of age-related diseases.
Overview of apoptosis signaling networks, antibodies and related reagents, interactive pathway diagrams, and technical resources for apoptosis research.
In response to a variety of environmental factors, cells may permanently cease proliferation and enter a state known as cellular senescence.
Cell states can be monitored using markers correlating to your process of interest. These assays and antibodies can be used to detect cell viability, senescence, proliferation, apoptosis, cytotoxicity and oxidative state.
Co-staining with multiple antibodies is a low-content form of multiplex analysis that be achieved using different host species or fluorophore conjugates.
Cellular senescence is defined by permanent cell cycle arrest. Senescent cells accumulate with age and contribute to normal aging and age-related disorders
There are many reasons to include a subcellular marker in your IF experiment: studying organelle-specific functions, assessing drug effects, and more.
Apoptosis is a regulated form of programmed cell death (PCD) that occurs without external influence.
Expert-reviewed interactive pathway providing a current overview of Death Receptor Signaling.
Streamline your oncology therapeutic development with CST recombinant monoclonal antibodies, ELISA and cellular assay kits, custom products, and services.
The PI3K / Akt Substrates Table provides a comprehensive list of demonstrated downstream targets of Akt phosphorylation.
Streamline your neurodegeneration therapeutic development with CST recombinant monoclonal antibodies, ELISA and cellular assay kits, custom products, and services.
Kinase-disease associations table showing kinases, kinase groups, disease types, and the molecular biology basis for disease.
Products and Related Resources for Adaptive Immune Response SARS-CoV-2 Research
Multiplex Oligos for Illumina Protocol (Single Index Primers) (ChIP-seq, CUT&RUN): easy to follow directions describing the step by step experimental procedure.a
Multiplex Oligos for Illumina Protocol (Dual Index Primers) (ChIP-seq, CUT&RUN): easy to follow directions describing the step by step experimental procedure.
Expert-reviewed diagram providing a current overview of the Mechanisms of Fibrosis pathway with references to its role in adhesion