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Epigenetic regulation, including aberrant DNA methylation and histone modifications, have been linked to Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis.
Click here to discover the intricacies of methylation pathways and their role in gene regulation and epigenetic modifications.
Ensure equal sample loading with loading control antibodies from CST.
Loading controls are essential to ensure data reliability in your western blot. Learn about the three main considerations for loading control selection.
Expert-reviewed interactive pathway providing a current overview of ATP-Dependent Chromatin Remodeling Complexes.
Expert-reviewed interactive pathway providing a current overview of Cell Cycle G1/S Checkpoint Signaling.
Explore the intricate Wnt Beta Catenin pathway & its role in cell development and disease. Learn more about the signaling cascade of this crucial pathway.
Expert-reviewed interactive pathway providing a current overview of PTM Crosstalk Signaling.
Explore the NFkB pathway and its impact on inflammation and immune responses. Click here to learn more about this signaling pathway.
Expert-reviewed interactive pathway providing a current overview of Protein Acetylation.
Expert-reviewed interactive pathway providing a current overview of Nuclear Receptor Signaling.
3D video animation of histone modifications and their effects on chromatin activation
A scientific resource for the BRCT protein domain containing information on structure, function, and binding to phospho-serine motifs.
The activity of genes and their regulatory elements is, in part, governed by their cell type-specific chromatin organization.
Interact with this diagram showing the epigenetic regulators of Histone H3 including those responsible for monomethylation, asymmetric and symmetric dimethylation, and trimethylation.
The nuclear receptor signaling plays important roles in cell differentiation, proliferation, metabolism, and other physiological processes. Click here.
Interact with this diagram showing the epigenetic writers and erasers of histone H2A, histone H2B, and Histone H4, including the involvement of acetyltransferases, deacetylases, methyltransferases, demethylases and kinases.
SimpleChIP Kits and Antibodies validated in-house by our antibody development scientists correlated to positive and negative control primers.
Overview of epigenetic and chromatin regulation pathways, antibodies and related reagents, interactive pathway diagrams, and technical resources for epigenetics research.
Several different assays can be used by scientists to measure metabolism in a variety of contexts. These include methods to determine metabolic rates, key signaling pathways, and environmental cues.
Alphabetical listing of protein, pathway, and antibody acronyms, curated by Cell Signaling Technology.
A number of growth factors and cytokines can induce an Epithelial-Mesenchymal Transition (EMT) in tumor cells.
Study the intricate Notch signaling pathway and its impact on cell fate determination and development. Click here to learn more.
Streamline your oncology therapeutic development with CST recombinant monoclonal antibodies, ELISA and cellular assay kits, custom products, and services.
Streamline your neurodegeneration therapeutic development with CST recombinant monoclonal antibodies, ELISA and cellular assay kits, custom products, and services.
List of publications based on primary research done by the Cancer Research Group at CST (2002-2013).
Find validated CST® matched antibody pairs and streamline the development of your High-Throughput ELISA-Like Immunoassays for screening.
A chronological listing of case studies and peer-reviewed publications utilizing PTMScan proteomic technology developed by Cell Signaling Technology.
A comprehensive list of peer-reviewed publications from Cell Signaling Technology.
